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Target Report Card

Target Name and Classification

Target ID CHEMBL1900
Target Type SINGLE PROTEIN
Preferred Name Aldose reductase
Synonyms AKR1B1 | ALDR1 | AR | Aldehyde reductase | Aldo-keto reductase family 1 member B1 | Aldose reductase
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Aldose reductase SINGLE PROTEIN P15121

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000085662
Ensembl ENSG00000085662
GO Cellular Component GO:0005615 (extracellular space)
GO:0005654 (nucleoplasm)
GO:0005737 (cytoplasm)
GO:0005829 (cytosol)
GO:0032838 (cell projection cytoplasm)
GO:0033010 (paranodal junction)
GO:0042629 (mast cell granule)
GO:0043220 (Schmidt-Lanterman incisure)
GO:0048471 (perinuclear region of cytoplasm)
GO:0070062 (extracellular exosome)
GO:0097454 (Schwann cell microvillus)
GO Molecular Function GO:0004032 (alditol:NADP+ 1-oxidoreductase activity)
GO:0004033 (aldo-keto reductase (NADP) activity)
GO:0009055 (electron carrier activity)
GO:0016491 (oxidoreductase activity)
GO:0043795 (glyceraldehyde oxidoreductase activity)
GO Biological Process GO:0001894 (tissue homeostasis)
GO:0005975 (carbohydrate metabolic process)
GO:0005996 (monosaccharide metabolic process)
GO:0006061 (sorbitol biosynthetic process)
GO:0006700 (C21-steroid hormone biosynthetic process)
GO:0006950 (response to stress)
GO:0009414 (response to water deprivation)
GO:0010033 (response to organic substance)
GO:0018931 (naphthalene metabolic process)
GO:0031098 (stress-activated protein kinase signaling cascade)
GO:0042415 (norepinephrine metabolic process)
GO:0044597 (daunorubicin metabolic process)
GO:0044598 (doxorubicin metabolic process)
GO:0046370 (fructose biosynthetic process)
GO:0046427 (positive regulation of JAK-STAT cascade)
GO:0048661 (positive regulation of smooth muscle cell proliferation)
GO:0055114 (oxidation-reduction process)
GO:0060135 (maternal process involved in female pregnancy)
GO:0070301 (cellular response to hydrogen peroxide)
GO:0072061 (inner medullary collecting duct development)
GO:0097066 (response to thyroid hormone)
GO:0097238 (cellular response to methylglyoxal)
GO:1901653 (cellular response to peptide)
Wikipedia AKR1B1

Target Cross References - Protein

canSAR P15121
Human Protein Atlas ENSG00000085662
IntAct P15121
Guide to Pharmacology 2768
Open Targets ENSG00000085662
PharmGKB PA24675
Reactome R-HSA-196108 (Pregnenolone biosynthesis.)
R-HSA-5652227 (Fructose biosynthesis.)
UniProt B2R8N3 P15121 Q5U031 Q6FGA4 Q6ICP2 Q9BS21 Q9UCI9

Target Cross References - Domain

InterPro IPR018170 (Aldo/ket_reductase_CS.)
IPR020471 (Aldo/keto_reductase.)
IPR023210 (NADP_OxRdtase_dom.)
Pfam PF00248 (Aldo_ket_red)

Target Cross References - Structure

PDBe 1ABN 1ADS 1AZ1 1AZ2 1EF3 1EL3 1IEI 1MAR 1PWL 1PWM 1T40 1T41 1US0 1X96 1X97 1X98 1XGD 1Z3N 1Z89 1Z8A 2ACQ 2ACR 2ACS 2ACU More...
CREDO 1ABN 1ADS 1AZ1 1AZ2 1EF3 1EL3 1IEI 1MAR 1PWL 1PWM 1T40 1T41 1US0 1X96 1X97 1X98 1XGD 1Z3N 1Z89 1Z8A 2ACQ 2ACR 2ACS 2ACU More...
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