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Target Report Card

Target Name and Classification

Target ID CHEMBL1898
Preferred Name Serotonin 1b (5-HT1b) receptor
Synonyms 5-HT-1B | 5-HT-1D-beta | 5-HT1B | 5-hydroxytryptamine receptor 1B | HTR1B | HTR1DB | S12 | Serotonin 1D beta receptor | Serotonin receptor 1B
Organism Homo sapiens
Species Group No
Protein Target Classification
  • membrane receptor > family a g protein-coupled receptor > small molecule receptor (family a gpcr) > monoamine receptor > serotonin receptor

Target Components

Component Description Relationship Accession
5-hydroxytryptamine receptor 1B SINGLE PROTEIN P28222

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2095230 Serotonin 1 receptors; 5-HT1B & 5-HT1D SELECTIVITY GROUP
CHEMBL2096904 Serotonin (5-HT) receptor PROTEIN FAMILY

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL128 SUMATRIPTAN Serotonin 1b (5-HT1b) receptor agonist 4 FDA
CHEMBL1185 ZOLMITRIPTAN Serotonin 1b (5-HT1b) receptor agonist 4 FDA
CHEMBL1200521 ALMOTRIPTAN MALATE Serotonin 1b (5-HT1b) receptor agonist 4 FDA
CHEMBL1200601 NARATRIPTAN HYDROCHLORIDE Serotonin 1b (5-HT1b) receptor agonist 4 FDA
CHEMBL1201003 ELETRIPTAN HYDROBROMIDE Serotonin 1b (5-HT1b) receptor agonist 4 FDA
CHEMBL1201032 RIZATRIPTAN BENZOATE Serotonin 1b (5-HT1b) receptor agonist 4 FDA
CHEMBL1201150 SUMATRIPTAN SUCCINATE Serotonin 1b (5-HT1b) receptor agonist 4 FDA
CHEMBL2138684 FROVATRIPTAN SUCCINATE Serotonin 1b (5-HT1b) receptor agonist 4 FDA
CHEMBL2311030 ERGOLOID MESYLATES Serotonin 1b (5-HT1b) receptor agonist 4 ISBN PubMed
CHEMBL1631540 GSK163090 Serotonin 1b (5-HT1b) receptor antagonist 2 PubMed
CHEMBL1742428 DONITRIPTAN Serotonin 1b (5-HT1b) receptor agonist 2 PubMed
CHEMBL3183740 TRELANSERIN Serotonin 1b (5-HT1b) receptor antagonist 2 PubMed PubMed
CHEMBL3989805 ELZASONAN HYDROCHLORIDE Serotonin 1b (5-HT1b) receptor antagonist 2 PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000135312
Ensembl ENSG00000135312
GO Cellular Component GO:0005737 (cytoplasm)
GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO Molecular Function GO:0004871 (signal transducer activity)
GO:0004930 (G-protein coupled receptor activity)
GO:0004993 (G-protein coupled serotonin receptor activity)
GO:0005515 (protein binding)
GO:0008144 (drug binding)
GO:0030594 (neurotransmitter receptor activity)
GO:0051378 (serotonin binding)
GO Biological Process GO:0002031 (G-protein coupled receptor internalization)
GO:0007165 (signal transduction)
GO:0007186 (G-protein coupled receptor signaling pathway)
GO:0007187 (G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)
GO:0007193 (adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway)
GO:0007198 (adenylate cyclase-inhibiting serotonin receptor signaling pathway)
GO:0007205 (protein kinase C-activating G-protein coupled receptor signaling pathway)
GO:0007268 (chemical synaptic transmission)
GO:0007610 (behavior)
GO:0007631 (feeding behavior)
GO:0014059 (regulation of dopamine secretion)
GO:0014063 (negative regulation of serotonin secretion)
GO:0032229 (negative regulation of synaptic transmission, GABAergic)
GO:0035690 (cellular response to drug)
GO:0042220 (response to cocaine)
GO:0042310 (vasoconstriction)
GO:0042493 (response to drug)
GO:0042756 (drinking behavior)
GO:0045471 (response to ethanol)
GO:0046849 (bone remodeling)
GO:0050795 (regulation of behavior)
GO:0051385 (response to mineralocorticoid)
GO:0051967 (negative regulation of synaptic transmission, glutamatergic)
GO:0071312 (cellular response to alkaloid)
GO:0071502 (cellular response to temperature stimulus)
GO:1904707 (positive regulation of vascular smooth muscle cell proliferation)
Wikipedia 5-HT1B_receptor

Target Cross References - Protein

canSAR P28222
Human Protein Atlas ENSG00000135312
IntAct P28222
Guide to Pharmacology 2
MICAD NBK23439 (5-HT1B serotonin receptors)
Open Targets ENSG00000135312
PharmGKB PA29549
Pharos P28222 (Tclin)
Reactome R-HSA-390666 (Serotonin receptors.)
R-HSA-418594 (G alpha (i) signalling events.)
UniProt P28222 Q4VAY7

Target Cross References - Domain

InterPro IPR000276 (GPCR_Rhodpsn.)
IPR002147 (5HT1B_rcpt.)
IPR002231 (5HT_rcpt.)
IPR017452 (GPCR_Rhodpsn_7TM.)
Pfam PF00001 (7tm_1)

Target Cross References - Structure