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Target Report Card

Target Name and Classification

Target ID CHEMBL1883
Preferred Name Neuronal acetylcholine receptor protein beta-2 subunit
Synonyms CHRNB2 | Neuronal acetylcholine receptor subunit beta-2
Organism Homo sapiens
Species Group No
Protein Target Classification
  • ion channel > ligand-gated ion channel > nicotinic acetylcholine receptor > nicotinic acetylcholine receptor beta subunit

Target Components

Component Description Relationship Accession
Neuronal acetylcholine receptor subunit beta-2 SINGLE PROTEIN P17787

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2109236 Neuronal acetylcholine receptor; alpha2/beta2 PROTEIN COMPLEX
CHEMBL3137272 Nicotinic acetylcholine receptor alpha3/beta2/alpha5 PROTEIN COMPLEX
CHEMBL3885595 Integrin alpha-5/Neuronal acetylcholine receptor subunit alpha-3/Neuronal acetylcholine receptor subunit beta-2/Neuronal acetylcholine receptor subunit beta-4 PROTEIN COMPLEX
CHEMBL2109237 Neuronal acetylcholine receptor; alpha6/beta2 PROTEIN COMPLEX
CHEMBL2221346 Neuronal acetylcholine receptors; alpha-3/beta-4, alpha-5, beta-2 PROTEIN COMPLEX GROUP
CHEMBL2111384 Nicotinic acetylcholine receptor alpha3/betaX PROTEIN COMPLEX GROUP
CHEMBL1907589 Neuronal acetylcholine receptor; alpha4/beta2 PROTEIN COMPLEX
CHEMBL3038458 Nicotinic acetylcholine receptor alpha2/beta2 PROTEIN COMPLEX
CHEMBL3038461 Nicotinic acetylcholine receptor alpha4/beta2/alpha5 PROTEIN COMPLEX
CHEMBL2109234 Neuronal acetylcholine receptor; alpha3/beta2 PROTEIN COMPLEX
CHEMBL2109233 Neuronal acetylcholine receptor; alpha3/alpha6/beta2/beta3 PROTEIN COMPLEX

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000160716
Ensembl ENSG00000160716
GO Cellular Component GO:0005886 (plasma membrane)
GO:0005892 (acetylcholine-gated channel complex)
GO:0009897 (external side of plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0030054 (cell junction)
GO:0044853 (plasma membrane raft)
GO:0045202 (synapse)
GO:0045211 (postsynaptic membrane)
GO Molecular Function GO:0004888 (transmembrane signaling receptor activity)
GO:0005216 (ion channel activity)
GO:0005230 (extracellular ligand-gated ion channel activity)
GO:0005515 (protein binding)
GO:0008144 (drug binding)
GO:0015276 (ligand-gated ion channel activity)
GO:0015464 (acetylcholine receptor activity)
GO:0022848 (acetylcholine-gated cation channel activity)
GO:0042166 (acetylcholine binding)
GO:0046982 (protein heterodimerization activity)
GO Biological Process GO:0001508 (action potential)
GO:0001661 (conditioned taste aversion)
GO:0001666 (response to hypoxia)
GO:0006811 (ion transport)
GO:0006816 (calcium ion transport)
GO:0006939 (smooth muscle contraction)
GO:0007165 (signal transduction)
GO:0007271 (synaptic transmission, cholinergic)
GO:0007274 (neuromuscular synaptic transmission)
GO:0007601 (visual perception)
GO:0007605 (sensory perception of sound)
GO:0007612 (learning)
GO:0007613 (memory)
GO:0007626 (locomotory behavior)
GO:0008306 (associative learning)
GO:0008542 (visual learning)
GO:0014059 (regulation of dopamine secretion)
GO:0019233 (sensory perception of pain)
GO:0021562 (vestibulocochlear nerve development)
GO:0021631 (optic nerve morphogenesis)
GO:0021771 (lateral geniculate nucleus development)
GO:0021952 (central nervous system projection neuron axonogenesis)
GO:0021955 (central nervous system neuron axonogenesis)
GO:0030890 (positive regulation of B cell proliferation)
GO:0032225 (regulation of synaptic transmission, dopaminergic)
GO:0032226 (positive regulation of synaptic transmission, dopaminergic)
GO:0033603 (positive regulation of dopamine secretion)
GO:0034220 (ion transmembrane transport)
GO:0035094 (response to nicotine)
GO:0035095 (behavioral response to nicotine)
GO:0035176 (social behavior)
GO:0042053 (regulation of dopamine metabolic process)
GO:0042113 (B cell activation)
GO:0042220 (response to cocaine)
GO:0042320 (regulation of circadian sleep/wake cycle, REM sleep)
GO:0042391 (regulation of membrane potential)
GO:0045188 (regulation of circadian sleep/wake cycle, non-REM sleep)
GO:0045471 (response to ethanol)
GO:0045759 (negative regulation of action potential)
GO:0048814 (regulation of dendrite morphogenesis)
GO:0050877 (neurological system process)
GO:0050890 (cognition)
GO:0051291 (protein heterooligomerization)
GO:0051899 (membrane depolarization)
GO:0051963 (regulation of synapse assembly)
GO:0060078 (regulation of postsynaptic membrane potential)
GO:0060079 (excitatory postsynaptic potential)
GO:0060084 (synaptic transmission involved in micturition)
GO:0095500 (acetylcholine receptor signaling pathway)
GO:1905144 (response to acetylcholine)
Wikipedia CHRNB2

Target Cross References - Protein

canSAR P17787
CGD Epilepsy, nocturnal frontal lobe, type 3
Human Protein Atlas ENSG00000160716
IntAct P17787
Open Targets ENSG00000160716
PharmGKB PA115
Pharos P17787 (Tclin)
Reactome R-HSA-629587 (Highly sodium permeable acetylcholine nicotinic receptors.)
R-HSA-629594 (Highly calcium permeable postsynaptic nicotinic acetylcholine receptors.)
R-HSA-629597 (Highly calcium permeable nicotinic acetylcholine receptors.)
UniProt P17787 Q9UEH9

Target Cross References - Domain

InterPro IPR002394 (Nicotinic_acetylcholine_rcpt.)
IPR006029 (Neurotrans-gated_channel_TM.)
IPR006201 (Neur_channel.)
IPR006202 (Neur_chan_lig-bd.)
IPR018000 (Neurotransmitter_ion_chnl_CS.)
IPR032932 (CHRNB2.)
IPR036719 (Neuro-gated_channel_TM_sf.)
IPR036734 (Neur_chan_lig-bd_sf.)
Pfam PF02931 (Neur_chan_LBD)
PF02932 (Neur_chan_memb)

Target Cross References - Structure