ChEMBL logo


ChEMBL Statistics
  Loading Statistics...

Target Report Card

Target Name and Classification

Target ID CHEMBL1882
Preferred Name Neuronal acetylcholine receptor protein alpha-4 subunit
Synonyms CHRNA4 | NACRA4 | Neuronal acetylcholine receptor subunit alpha-4
Organism Homo sapiens
Species Group No
Protein Target Classification
  • ion channel > ligand-gated ion channel > nicotinic acetylcholine receptor > nicotinic acetylcholine receptor alpha subunit

Target Components

Component Description Relationship Accession
Neuronal acetylcholine receptor subunit alpha-4 SINGLE PROTEIN P43681

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL1907589 Neuronal acetylcholine receptor; alpha4/beta2 PROTEIN COMPLEX
CHEMBL1907591 Neuronal acetylcholine receptor; alpha4/beta4 PROTEIN COMPLEX
CHEMBL3038461 Nicotinic acetylcholine receptor alpha4/beta2/alpha5 PROTEIN COMPLEX

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000101204
Ensembl ENSG00000101204
GO Cellular Component GO:0005886 (plasma membrane)
GO:0005892 (acetylcholine-gated channel complex)
GO:0009897 (external side of plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0030054 (cell junction)
GO:0030425 (dendrite)
GO:0043025 (neuronal cell body)
GO:0045202 (synapse)
GO:0045211 (postsynaptic membrane)
GO Molecular Function GO:0004888 (transmembrane signaling receptor activity)
GO:0005216 (ion channel activity)
GO:0005230 (extracellular ligand-gated ion channel activity)
GO:0005515 (protein binding)
GO:0015276 (ligand-gated ion channel activity)
GO:0015464 (acetylcholine receptor activity)
GO:0022848 (acetylcholine-gated cation channel activity)
GO:0042166 (acetylcholine binding)
GO Biological Process GO:0001508 (action potential)
GO:0001666 (response to hypoxia)
GO:0006281 (DNA repair)
GO:0006811 (ion transport)
GO:0006816 (calcium ion transport)
GO:0006979 (response to oxidative stress)
GO:0007165 (signal transduction)
GO:0007268 (chemical synaptic transmission)
GO:0007271 (synaptic transmission, cholinergic)
GO:0007274 (neuromuscular synaptic transmission)
GO:0007585 (respiratory gaseous exchange)
GO:0007626 (locomotory behavior)
GO:0014059 (regulation of dopamine secretion)
GO:0019233 (sensory perception of pain)
GO:0034220 (ion transmembrane transport)
GO:0035094 (response to nicotine)
GO:0035095 (behavioral response to nicotine)
GO:0035640 (exploration behavior)
GO:0042113 (B cell activation)
GO:0042391 (regulation of membrane potential)
GO:0050877 (neurological system process)
GO:0050890 (cognition)
GO:0051899 (membrane depolarization)
GO:0060079 (excitatory postsynaptic potential)
GO:0060080 (inhibitory postsynaptic potential)
GO:0095500 (acetylcholine receptor signaling pathway)
Wikipedia CHRNA4

Target Cross References - Protein

canSAR P43681
CGD Epilepsy, nocturnal frontal lobe, type 1
Human Protein Atlas ENSG00000101204
IntAct P43681
Guide to Pharmacology 465
Open Targets ENSG00000101204
PharmGKB PA26490
Pharos P43681 (Tclin)
Reactome R-HSA-629587 (Highly sodium permeable acetylcholine nicotinic receptors.)
R-HSA-629594 (Highly calcium permeable postsynaptic nicotinic acetylcholine receptors.)
R-HSA-629597 (Highly calcium permeable nicotinic acetylcholine receptors.)
UniProt P43681 Q4JGR7 Q4VAQ5 Q4VAQ6

Target Cross References - Domain

InterPro IPR002394 (Nicotinic_acetylcholine_rcpt.)
IPR006029 (Neurotrans-gated_channel_TM.)
IPR006201 (Neur_channel.)
IPR006202 (Neur_chan_lig-bd.)
IPR018000 (Neurotransmitter_ion_chnl_CS.)
IPR036719 (Neuro-gated_channel_TM_sf.)
IPR036734 (Neur_chan_lig-bd_sf.)
Pfam PF02931 (Neur_chan_LBD)
PF02932 (Neur_chan_memb)

Target Cross References - Structure