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Target Report Card

Target Name and Classification

Target ID CHEMBL1867
Preferred Name Alpha-2a adrenergic receptor
Synonyms ADRA2A | ADRA2R | ADRAR | Alpha-2 adrenergic receptor subtype C10 | Alpha-2A adrenergic receptor | Alpha-2A adrenoceptor | Alpha-2A adrenoreceptor | Alpha-2AAR
Organism Homo sapiens
Species Group No
Protein Target Classification
  • membrane receptor > family a g protein-coupled receptor > small molecule receptor (family a gpcr) > monoamine receptor > adrenergic receptor

Target Components

Component Description Relationship Accession
Alpha-2A adrenergic receptor SINGLE PROTEIN P08913

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL3885512 Adenosine receptor A1/Alpha-2A adrenergic receptor PROTEIN COMPLEX
CHEMBL2095203 Adrenergic receptor alpha PROTEIN FAMILY
CHEMBL2095158 Adrenergic receptor alpha-2 PROTEIN FAMILY
CHEMBL2331074 Adrenergic receptor PROTEIN FAMILY
CHEMBL3883321 Mu opioid receptor/Alpha-2A adrenergic receptor PROTEIN COMPLEX

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000150594
Ensembl ENSG00000150594
GO Cellular Component GO:0005737 (cytoplasm)
GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0016323 (basolateral plasma membrane)
GO:0043235 (receptor complex)
GO Molecular Function GO:0004871 (signal transducer activity)
GO:0004930 (G-protein coupled receptor activity)
GO:0004935 (adrenergic receptor activity)
GO:0004938 (alpha2-adrenergic receptor activity)
GO:0005515 (protein binding)
GO:0019901 (protein kinase binding)
GO:0031692 (alpha-1B adrenergic receptor binding)
GO:0031696 (alpha-2C adrenergic receptor binding)
GO:0031996 (thioesterase binding)
GO:0032795 (heterotrimeric G-protein binding)
GO:0042803 (protein homodimerization activity)
GO:0046982 (protein heterodimerization activity)
GO:0051379 (epinephrine binding)
GO:0051380 (norepinephrine binding)
GO Biological Process GO:0001819 (positive regulation of cytokine production)
GO:0006940 (regulation of smooth muscle contraction)
GO:0007165 (signal transduction)
GO:0007186 (G-protein coupled receptor signaling pathway)
GO:0007193 (adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway)
GO:0007265 (Ras protein signal transduction)
GO:0007266 (Rho protein signal transduction)
GO:0008284 (positive regulation of cell proliferation)
GO:0010700 (negative regulation of norepinephrine secretion)
GO:0019229 (regulation of vasoconstriction)
GO:0030036 (actin cytoskeleton organization)
GO:0030168 (platelet activation)
GO:0030335 (positive regulation of cell migration)
GO:0032147 (activation of protein kinase activity)
GO:0032148 (activation of protein kinase B activity)
GO:0032811 (negative regulation of epinephrine secretion)
GO:0032870 (cellular response to hormone stimulus)
GO:0035625 (epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway)
GO:0042593 (glucose homeostasis)
GO:0043268 (positive regulation of potassium ion transport)
GO:0043406 (positive regulation of MAP kinase activity)
GO:0043410 (positive regulation of MAPK cascade)
GO:0045741 (positive regulation of epidermal growth factor-activated receptor activity)
GO:0045955 (negative regulation of calcium ion-dependent exocytosis)
GO:0046676 (negative regulation of insulin secretion)
GO:0050796 (regulation of insulin secretion)
GO:0050892 (intestinal absorption)
GO:0050995 (negative regulation of lipid catabolic process)
GO:0051044 (positive regulation of membrane protein ectodomain proteolysis)
GO:0051926 (negative regulation of calcium ion transport)
GO:0061179 (negative regulation of insulin secretion involved in cellular response to glucose stimulus)
GO:0071875 (adrenergic receptor signaling pathway)
GO:0071878 (negative regulation of adrenergic receptor signaling pathway)
GO:0071880 (adenylate cyclase-activating adrenergic receptor signaling pathway)
GO:0071881 (adenylate cyclase-inhibiting adrenergic receptor signaling pathway)
GO:0071882 (phospholipase C-activating adrenergic receptor signaling pathway)
GO:0090303 (positive regulation of wound healing)
GO:0106072 (negative regulation of adenylate cyclase-activating G-protein coupled receptor signaling pathway)
GO:1901020 (negative regulation of calcium ion transmembrane transporter activity)
Wikipedia Alpha-2A_adrenergic_receptor

Target Cross References - Protein

canSAR P08913
Human Protein Atlas ENSG00000150594
IntAct P08913
Guide to Pharmacology 25
Open Targets ENSG00000150594
PharmGKB PA35
Pharos P08913 (Tclin)
Reactome R-HSA-390696 (Adrenoceptors.)
R-HSA-392023 (Adrenaline signalling through Alpha-2 adrenergic receptor.)
R-HSA-400042 (Adrenaline,noradrenaline inhibits insulin secretion.)
R-HSA-418594 (G alpha (i) signalling events.)
R-HSA-418597 (G alpha (z) signalling events.)
R-HSA-5683826 (Surfactant metabolism.)
UniProt B0LPF6 P08913 Q2I8G2 Q2XN99 Q86TH8 Q9BZK1

Target Cross References - Domain

InterPro IPR000276 (GPCR_Rhodpsn.)
IPR001946 (ADRA2A_rcpt.)
IPR002233 (ADR_fam.)
IPR017452 (GPCR_Rhodpsn_7TM.)
Pfam PF00001 (7tm_1)