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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL1847
Preferred Name GABA receptor beta-3 subunit
Synonyms GABA(A) receptor subunit beta-3 | GABRB3 | Gamma-aminobutyric acid receptor subunit beta-3
Organism Homo sapiens
Species Group No
Protein Target Classification
  • ion channel > ligand-gated ion channel > gaba-a receptor

Target Components

Component Description Relationship Accession
Gamma-aminobutyric acid receptor subunit beta-3 SINGLE PROTEIN P28472

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL3885577 Gamma-aminobutyric acid receptor subunit alpha-5/beta-3/gamma-3 PROTEIN COMPLEX
CHEMBL2111366 GABA A receptor alpha-4/beta-3/gamma-2 PROTEIN COMPLEX
CHEMBL2094122 GABA-A receptor; alpha-5/beta-3/gamma-2 PROTEIN COMPLEX
CHEMBL3885578 Gamma-aminobutyric acid receptor subunit alpha-6/beta-3 PROTEIN COMPLEX
CHEMBL2095190 GABA-A receptor; alpha-6/beta-3/gamma-2 PROTEIN COMPLEX
CHEMBL2109244 GABA-A receptor; agonist GABA site PROTEIN COMPLEX GROUP
CHEMBL2094130 GABA-A receptor; alpha-2/beta-3/gamma-2 PROTEIN COMPLEX
CHEMBL2093872 GABA-A receptor; anion channel PROTEIN COMPLEX GROUP
CHEMBL4106151 GABA-A receptor alpha-1/beta-3 PROTEIN COMPLEX
CHEMBL3430899 Gamma-aminobutyric acid receptor subunit alpha-4/beta3/delta PROTEIN COMPLEX
CHEMBL3885573 Gamma-aminobutyric acid receptor subunit alpha-3/ beta-3/gamma-3 PROTEIN COMPLEX
CHEMBL3885575 Gamma-aminobutyric acid receptor subunit alpha-3/beta-3/theta PROTEIN COMPLEX
CHEMBL2094121 GABA-A receptor; alpha-1/beta-3/gamma-2 PROTEIN COMPLEX
CHEMBL4106157 GABA-A receptor alpha-4/beta-3/delta PROTEIN COMPLEX
CHEMBL3885574 Gamma-aminobutyric acid receptor subunit alpha-3/beta-3 PROTEIN COMPLEX
CHEMBL2094120 GABA-A receptor; alpha-3/beta-3/gamma-2 PROTEIN COMPLEX

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL356388 ETAZOLATE GABA receptor beta-3 subunit positive allosteric modulator 2 Other

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000166206
Ensembl ENSG00000166206
GO Cellular Component GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0030054 (cell junction)
GO:0030659 (cytoplasmic vesicle membrane)
GO:0031410 (cytoplasmic vesicle)
GO:0034707 (chloride channel complex)
GO:0043005 (neuron projection)
GO:0045202 (synapse)
GO:0045211 (postsynaptic membrane)
GO:0098982 (GABA-ergic synapse)
GO:1902711 (GABA-A receptor complex)
GO Molecular Function GO:0004888 (transmembrane signaling receptor activity)
GO:0004890 (GABA-A receptor activity)
GO:0005216 (ion channel activity)
GO:0005230 (extracellular ligand-gated ion channel activity)
GO:0005254 (chloride channel activity)
GO:0022851 (GABA-gated chloride ion channel activity)
GO:0042802 (identical protein binding)
GO:1904315 (transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)
GO Biological Process GO:0006811 (ion transport)
GO:0006821 (chloride transport)
GO:0007165 (signal transduction)
GO:0007214 (gamma-aminobutyric acid signaling pathway)
GO:0007268 (chemical synaptic transmission)
GO:0007605 (sensory perception of sound)
GO:0034220 (ion transmembrane transport)
GO:0042391 (regulation of membrane potential)
GO:0043523 (regulation of neuron apoptotic process)
GO:0043524 (negative regulation of neuron apoptotic process)
GO:0048666 (neuron development)
GO:0050877 (nervous system process)
GO:0060021 (roof of mouth development)
GO:0060080 (inhibitory postsynaptic potential)
GO:0060119 (inner ear receptor cell development)
GO:0060384 (innervation)
GO:0071420 (cellular response to histamine)
GO:0090102 (cochlea development)
GO:1901215 (negative regulation of neuron death)
GO:1902476 (chloride transmembrane transport)
Wikipedia GABRB3

Target Cross References - Protein

canSAR P28472
CGD Epilepsy, childhood absence, susceptibility to, 5
Human Protein Atlas ENSG00000166206
IntAct P28472
Guide to Pharmacology 412
Open Targets ENSG00000166206
PharmGKB PA28497
Pharos P28472 (Tclin)
Reactome R-HSA-112314 (Neurotransmitter receptors and postsynaptic signal transmission.)
R-HSA-977441 (GABA A receptor activation.)
UniProt B7Z2W1 B7Z825 F5H3D2 H7BYV8 P28472 Q14352 Q96FM5

Target Cross References - Domain

InterPro IPR002289 (GABAAb_rcpt.)
IPR006028 (GABAA/Glycine_rcpt.)
IPR006029 (Neurotrans-gated_channel_TM.)
IPR006201 (Neur_channel.)
IPR006202 (Neur_chan_lig-bd.)
IPR018000 (Neurotransmitter_ion_chnl_CS.)
IPR036719 (Neuro-gated_channel_TM_sf.)
IPR036734 (Neur_chan_lig-bd_sf.)
Pfam PF02931 (Neur_chan_LBD)
PF02932 (Neur_chan_memb)

Target Cross References - Structure