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Target Report Card

Target Name and Classification

Target ID CHEMBL1841
Preferred Name Tyrosine-protein kinase FYN
Synonyms FYN | Proto-oncogene Syn | Proto-oncogene c-Fyn | SLK | Src-like kinase | Tyrosine-protein kinase Fyn | p59-Fyn
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > tk protein kinase group > tyrosine protein kinase src family

Target Components

Component Description Relationship Accession
Tyrosine-protein kinase Fyn SINGLE PROTEIN P06241

Target Relations

ChEMBL ID Pref Name Target Type

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL3545133 JNJ-26483327 Tyrosine-protein kinase FYN inhibitor 1 DOI PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000010810
Ensembl ENSG00000010810
GO Cellular Component GO:0005634 (nucleus)
GO:0005737 (cytoplasm)
GO:0005739 (mitochondrion)
GO:0005768 (endosome)
GO:0005829 (cytosol)
GO:0005884 (actin filament)
GO:0005886 (plasma membrane)
GO:0014069 (postsynaptic density)
GO:0016020 (membrane)
GO:0030425 (dendrite)
GO:0031234 (extrinsic component of cytoplasmic side of plasma membrane)
GO:0043231 (intracellular membrane-bounded organelle)
GO:0045121 (membrane raft)
GO:0071944 (cell periphery)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0001664 (G-protein coupled receptor binding)
GO:0004672 (protein kinase activity)
GO:0004713 (protein tyrosine kinase activity)
GO:0004715 (non-membrane spanning protein tyrosine kinase activity)
GO:0004871 (signal transducer activity)
GO:0005088 (Ras guanyl-nucleotide exchange factor activity)
GO:0005102 (receptor binding)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0015631 (tubulin binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO:0019899 (enzyme binding)
GO:0031802 (type 5 metabotropic glutamate receptor binding)
GO:0042608 (T cell receptor binding)
GO:0042609 (CD4 receptor binding)
GO:0042610 (CD8 receptor binding)
GO:0042802 (identical protein binding)
GO:0043548 (phosphatidylinositol 3-kinase binding)
GO:0044325 (ion channel binding)
GO:0044877 (macromolecular complex binding)
GO:0046872 (metal ion binding)
GO:0046875 (ephrin receptor binding)
GO:0046934 (phosphatidylinositol-4,5-bisphosphate 3-kinase activity)
GO:0048156 (tau protein binding)
GO:0051428 (peptide hormone receptor binding)
GO:0070851 (growth factor receptor binding)
GO:0097718 (disordered domain specific binding)
GO Biological Process GO:0000165 (MAPK cascade)
GO:0001764 (neuron migration)
GO:0002223 (stimulatory C-type lectin receptor signaling pathway)
GO:0002250 (adaptive immune response)
GO:0002376 (immune system process)
GO:0006468 (protein phosphorylation)
GO:0006816 (calcium ion transport)
GO:0007166 (cell surface receptor signaling pathway)
GO:0007169 (transmembrane receptor protein tyrosine kinase signaling pathway)
GO:0007275 (multicellular organism development)
GO:0007411 (axon guidance)
GO:0007417 (central nervous system development)
GO:0007596 (blood coagulation)
GO:0007612 (learning)
GO:0007631 (feeding behavior)
GO:0008360 (regulation of cell shape)
GO:0010629 (negative regulation of gene expression)
GO:0010976 (positive regulation of neuron projection development)
GO:0014068 (positive regulation of phosphatidylinositol 3-kinase signaling)
GO:0016032 (viral process)
GO:0016310 (phosphorylation)
GO:0016477 (cell migration)
GO:0018108 (peptidyl-tyrosine phosphorylation)
GO:0019221 (cytokine-mediated signaling pathway)
GO:0030154 (cell differentiation)
GO:0030168 (platelet activation)
GO:0030900 (forebrain development)
GO:0031295 (T cell costimulation)
GO:0031397 (negative regulation of protein ubiquitination)
GO:0035556 (intracellular signal transduction)
GO:0036120 (cellular response to platelet-derived growth factor stimulus)
GO:0038083 (peptidyl-tyrosine autophosphorylation)
GO:0038096 (Fc-gamma receptor signaling pathway involved in phagocytosis)
GO:0042110 (T cell activation)
GO:0042127 (regulation of cell proliferation)
GO:0042177 (negative regulation of protein catabolic process)
GO:0042493 (response to drug)
GO:0042531 (positive regulation of tyrosine phosphorylation of STAT protein)
GO:0042981 (regulation of apoptotic process)
GO:0043123 (positive regulation of I-kappaB kinase/NF-kappaB signaling)
GO:0043524 (negative regulation of neuron apoptotic process)
GO:0045087 (innate immune response)
GO:0045471 (response to ethanol)
GO:0046777 (protein autophosphorylation)
GO:0046854 (phosphatidylinositol phosphorylation)
GO:0048010 (vascular endothelial growth factor receptor signaling pathway)
GO:0048013 (ephrin receptor signaling pathway)
GO:0048813 (dendrite morphogenesis)
GO:0050690 (regulation of defense response to virus by virus)
GO:0050730 (regulation of peptidyl-tyrosine phosphorylation)
GO:0050798 (activated T cell proliferation)
GO:0050852 (T cell receptor signaling pathway)
GO:0050900 (leukocyte migration)
GO:0050966 (detection of mechanical stimulus involved in sensory perception of pain)
GO:0051897 (positive regulation of protein kinase B signaling)
GO:0071363 (cellular response to growth factor stimulus)
GO:0071375 (cellular response to peptide hormone stimulus)
GO:0071560 (cellular response to transforming growth factor beta stimulus)
GO:0090314 (positive regulation of protein targeting to membrane)
GO:0097062 (dendritic spine maintenance)
GO:1900182 (positive regulation of protein localization to nucleus)
GO:1901216 (positive regulation of neuron death)
GO:1902951 (negative regulation of dendritic spine maintenance)
GO:1904645 (response to amyloid-beta)
GO:1905232 (cellular response to L-glutamate)
GO:1905430 (cellular response to glycine)
GO:1905477 (positive regulation of protein localization to membrane)
GO:1905664 (regulation of calcium ion import across plasma membrane)
GO:2001056 (positive regulation of cysteine-type endopeptidase activity)
GO:2001240 (negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)
Wikipedia FYN

Target Cross References - Protein

canSAR P06241
Human Protein Atlas ENSG00000010810
IntAct P06241
Guide to Pharmacology 2026
Open Targets ENSG00000010810
PharmGKB PA28454
Pharos P06241 (Tclin)
Reactome R-HSA-114604 (GPVI-mediated activation cascade.)
R-HSA-1227986 (Signaling by ERBB2.)
R-HSA-1257604 (PIP3 activates AKT signaling.)
R-HSA-1433557 (Signaling by SCF-KIT.)
R-HSA-1433559 (Regulation of KIT signaling.)
R-HSA-164944 (Nef and signal transduction.)
R-HSA-202733 (Cell surface interactions at the vascular wall.)
R-HSA-2029481 (FCGR activation.)
R-HSA-210990 (PECAM1 interactions.)
R-HSA-2219530 (Constitutive Signaling by Aberrant PI3K in Cancer.)
R-HSA-2424491 (DAP12 signaling.)
R-HSA-2682334 (EPH-Ephrin signaling.)
R-HSA-2730905 (Role of LAT2/NTAL/LAB on calcium mobilization.)
R-HSA-373753 (Nephrin family interactions.)
R-HSA-375165 (NCAM signaling for neurite out-growth.)
R-HSA-389356 (CD28 co-stimulation.)
R-HSA-389357 (CD28 dependent PI3K/Akt signaling.)
R-HSA-389359 (CD28 dependent Vav1 pathway.)
R-HSA-389513 (CTLA4 inhibitory signaling.)
R-HSA-3928662 (EPHB-mediated forward signaling.)
R-HSA-3928663 (EPHA-mediated growth cone collapse.)
R-HSA-3928664 (Ephrin signaling.)
R-HSA-3928665 (EPH-ephrin mediated repulsion of cells.)
R-HSA-399954 (Sema3A PAK dependent Axon repulsion.)
R-HSA-399955 (SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion.)
R-HSA-399956 (CRMPs in Sema3A signaling.)
R-HSA-418885 (DCC mediated attractive signaling.)
R-HSA-418886 (Netrin mediated repulsion signals.)
R-HSA-4420097 (VEGFA-VEGFR2 Pathway.)
R-HSA-5621480 (Dectin-2 family.)
R-HSA-5621575 (CD209 (DC-SIGN) signaling.)
R-HSA-5673001 (RAF/MAP kinase cascade.)
R-HSA-6811558 (PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling.)
R-HSA-75892 (Platelet Adhesion to exposed collagen.)
R-HSA-8866376 (Reelin signalling pathway.)
R-HSA-912631 (Regulation of signaling by CBL.)
R-HSA-983695 (Antigen activates B Cell Receptor (BCR) leading to generation of second messengers.)
UniProt B5BU57 E1P557 H0UI48 P06241 Q16248 Q5R3A6 Q5R3A7 Q8N5D7

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_dom.)
IPR000980 (SH2.)
IPR001245 (Ser-Thr/Tyr_kinase_cat_dom.)
IPR001452 (SH3_domain.)
IPR008266 (Tyr_kinase_AS.)
IPR011009 (Kinase-like_dom_sf.)
IPR017441 (Protein_kinase_ATP_BS.)
IPR020635 (Tyr_kinase_cat_dom.)
IPR035750 (Fyn/Yrk_SH3.)
IPR036028 (SH3-like_dom_sf.)
IPR036860 (SH2_dom_sf.)
Pfam PF00017 (SH2)
PF00018 (SH3_1)
PF07714 (Pkinase_Tyr)

Target Cross References - Structure

PDBe 1AVZ 1EFN 1FYN 1G83 1M27 1SHF 2DQ7 3H0F 3H0H 3H0I 3UA6 3UA7 4D8D 4EIK 4U17 4U1P 4ZNX
CREDO 1AVZ 1EFN 1FYN 1G83 1M27 1SHF 2DQ7 3H0F 3H0H 3H0I 3UA6 3UA7 4D8D 4EIK 4U17 4U1P 4ZNX