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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL1808
Target Type SINGLE PROTEIN
Preferred Name Angiotensin-converting enzyme
Synonyms ACE | ACE | Angiotensin-converting enzyme | Angiotensin-converting enzyme, soluble form | CD_antigen=CD143 | DCP | DCP1 | Dipeptidyl carboxypeptidase I | Kininase II
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > protease > metallo protease > metallo protease mae clan > metallo protease m2 family

Target Components

Component Description Relationship Accession
Angiotensin-converting enzyme SINGLE PROTEIN P12821

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2096989 Angiotensin-converting enzyme PROTEIN FAMILY

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL1168 RAMIPRIL Angiotensin-converting enzyme inhibitor 4 DailyMed FDA
CHEMBL1519 TRANDOLAPRIL Angiotensin-converting enzyme inhibitor 4 DailyMed
CHEMBL1560 CAPTOPRIL Angiotensin-converting enzyme inhibitor 4 DailyMed FDA
CHEMBL1694 BENAZEPRIL HYDROCHLORIDE Angiotensin-converting enzyme inhibitor 4 DailyMed
CHEMBL1200343 PERINDOPRIL ERBUMINE Angiotensin-converting enzyme inhibitor 4 DailyMed FDA
CHEMBL1200534 MOEXIPRIL HYDROCHLORIDE Angiotensin-converting enzyme inhibitor 4 DailyMed
CHEMBL1200659 ENALAPRIL MALEATE Angiotensin-converting enzyme inhibitor 4 DailyMed FDA
CHEMBL1200697 ENALAPRILAT HYDRATE Angiotensin-converting enzyme inhibitor 4 DailyMed FDA
CHEMBL1200831 SPIRAPRIL HYDROCHLORIDE Angiotensin-converting enzyme inhibitor 4 PubMed
CHEMBL1201011 QUINAPRIL HYDROCHLORIDE Angiotensin-converting enzyme inhibitor 4 DailyMed
CHEMBL1729579 LISINOPRIL HYDRATE Angiotensin-converting enzyme inhibitor 4 DailyMed FDA
CHEMBL3039596 FOSINOPRIL SODIUM Angiotensin-converting enzyme inhibitor 4 DailyMed FDA
CHEMBL3544986 PERINDOPRIL ARGININE Angiotensin-converting enzyme inhibitor 4 FDA
More...

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000159640
Ensembl ENSG00000159640
GO Cellular Component GO:0005576 (extracellular region)
GO:0005615 (extracellular space)
GO:0005737 (cytoplasm)
GO:0005764 (lysosome)
GO:0005768 (endosome)
GO:0005886 (plasma membrane)
GO:0009897 (external side of plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0070062 (extracellular exosome)
GO Molecular Function GO:0003779 (actin binding)
GO:0004175 (endopeptidase activity)
GO:0004180 (carboxypeptidase activity)
GO:0005515 (protein binding)
GO:0008144 (drug binding)
GO:0008233 (peptidase activity)
GO:0008237 (metallopeptidase activity)
GO:0008238 (exopeptidase activity)
GO:0008240 (tripeptidyl-peptidase activity)
GO:0008241 (peptidyl-dipeptidase activity)
GO:0008270 (zinc ion binding)
GO:0016787 (hydrolase activity)
GO:0031404 (chloride ion binding)
GO:0031434 (mitogen-activated protein kinase kinase binding)
GO:0031711 (bradykinin receptor binding)
GO:0046872 (metal ion binding)
GO:0051019 (mitogen-activated protein kinase binding)
GO:0070573 (metallodipeptidase activity)
GO Biological Process GO:0001822 (kidney development)
GO:0001974 (blood vessel remodeling)
GO:0002003 (angiotensin maturation)
GO:0002005 (angiotensin catabolic process in blood)
GO:0002019 (regulation of renal output by angiotensin)
GO:0002446 (neutrophil mediated immunity)
GO:0002474 (antigen processing and presentation of peptide antigen via MHC class I)
GO:0003081 (regulation of systemic arterial blood pressure by renin-angiotensin)
GO:0006508 (proteolysis)
GO:0007283 (spermatogenesis)
GO:0008217 (regulation of blood pressure)
GO:0014910 (regulation of smooth muscle cell migration)
GO:0019229 (regulation of vasoconstriction)
GO:0032943 (mononuclear cell proliferation)
GO:0042312 (regulation of vasodilation)
GO:0042447 (hormone catabolic process)
GO:0043171 (peptide catabolic process)
GO:0050435 (beta-amyloid metabolic process)
GO:0050482 (arachidonic acid secretion)
GO:0060047 (heart contraction)
GO:0060177 (regulation of angiotensin metabolic process)
GO:0060218 (hematopoietic stem cell differentiation)
GO:0061098 (positive regulation of protein tyrosine kinase activity)
GO:0071838 (cell proliferation in bone marrow)
GO:1900086 (positive regulation of peptidyl-tyrosine autophosphorylation)
GO:1902033 (regulation of hematopoietic stem cell proliferation)
GO:1903597 (negative regulation of gap junction assembly)
GO:2000170 (positive regulation of peptidyl-cysteine S-nitrosylation)
Wikipedia Angiotensin-converting_enzyme

Target Cross References - Protein

canSAR P12821
CGD Renal tubular dysgenesis; ACE serum levels
Human Protein Atlas ENSG00000159640
IntAct P12821
Guide to Pharmacology 1613
MICAD NBK23120 (Angiotensin-converting enzyme (ACE))
Open Targets ENSG00000159640
PharmGKB PA139
Reactome R-HSA-2022377 (Metabolism of Angiotensinogen to Angiotensins.)
UniProt B0LPF0 B4DXI3 E7EU16 P12821 P22966 Q53YX9 Q59GY8 Q7M4L4

Target Cross References - Domain

InterPro IPR001548 (Peptidase_M2.)
Pfam PF01401 (Peptidase_M2)

Target Cross References - Structure

PDBe 1O86 1O8A 1UZE 1UZF 2C6F 2C6N 2IUL 2IUX 2OC2 2XY9 2XYD 2YDM 3BKK 3BKL 3L3N 3NXQ 4APH 4APJ 4BXK 4BZR 4BZS 4C2N 4C2O 4C2P More...
CREDO 1O86 1O8A 1UZE 1UZF 2C6F 2C6N 2IUL 2IUX 2OC2 2XY9 2XYD 2YDM 3BKK 3BKL 3L3N 3NXQ 4APH 4APJ 4BXK 4BZR 4BZS 4C2N 4C2O 4C2P More...
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