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Target Report Card

Target Name and Classification

Target ID CHEMBL1807
Preferred Name Sodium/potassium-transporting ATPase alpha-1 chain
Synonyms ATP1A1 | Na(+)/K(+) ATPase alpha-1 subunit | Sodium pump subunit alpha-1 | Sodium/potassium-transporting ATPase subunit alpha-1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • transporter > primary active transporter > p-type atpase > sodium potassium atpase
  • enzyme > hydrolase

Target Components

Component Description Relationship Accession
Sodium/potassium-transporting ATPase subunit alpha-1 SINGLE PROTEIN P05023

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2095186 Sodium/potassium-transporting ATPase PROTEIN COMPLEX GROUP

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000163399
Ensembl ENSG00000163399
GO Cellular Component GO:0005768 (endosome)
GO:0005783 (endoplasmic reticulum)
GO:0005794 (Golgi apparatus)
GO:0005886 (plasma membrane)
GO:0005890 (sodium:potassium-exchanging ATPase complex)
GO:0005901 (caveola)
GO:0014069 (postsynaptic density)
GO:0014704 (intercalated disc)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0016323 (basolateral plasma membrane)
GO:0016324 (apical plasma membrane)
GO:0030315 (T-tubule)
GO:0032991 (macromolecular complex)
GO:0042383 (sarcolemma)
GO:0042470 (melanosome)
GO:0043209 (myelin sheath)
GO:0045121 (membrane raft)
GO:0070062 (extracellular exosome)
GO:1903561 (extracellular vesicle)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0005391 (sodium:potassium-exchanging ATPase activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0016787 (hydrolase activity)
GO:0016791 (phosphatase activity)
GO:0019901 (protein kinase binding)
GO:0019904 (protein domain specific binding)
GO:0030506 (ankyrin binding)
GO:0030955 (potassium ion binding)
GO:0031402 (sodium ion binding)
GO:0043531 (ADP binding)
GO:0043548 (phosphatidylinositol 3-kinase binding)
GO:0046872 (metal ion binding)
GO:0051087 (chaperone binding)
GO:1990239 (steroid hormone binding)
GO Biological Process GO:0002026 (regulation of the force of heart contraction)
GO:0002028 (regulation of sodium ion transport)
GO:0006811 (ion transport)
GO:0006813 (potassium ion transport)
GO:0006814 (sodium ion transport)
GO:0006883 (cellular sodium ion homeostasis)
GO:0008217 (regulation of blood pressure)
GO:0010107 (potassium ion import)
GO:0010248 (establishment or maintenance of transmembrane electrochemical gradient)
GO:0016311 (dephosphorylation)
GO:0030007 (cellular potassium ion homeostasis)
GO:0031947 (negative regulation of glucocorticoid biosynthetic process)
GO:0034220 (ion transmembrane transport)
GO:0036376 (sodium ion export from cell)
GO:0042493 (response to drug)
GO:0045822 (negative regulation of heart contraction)
GO:0045823 (positive regulation of heart contraction)
GO:0045989 (positive regulation of striated muscle contraction)
GO:0055119 (relaxation of cardiac muscle)
GO:0060081 (membrane hyperpolarization)
GO:0071260 (cellular response to mechanical stimulus)
GO:0071383 (cellular response to steroid hormone stimulus)
GO:0086002 (cardiac muscle cell action potential involved in contraction)
GO:0086004 (regulation of cardiac muscle cell contraction)
GO:0086009 (membrane repolarization)
GO:0086013 (membrane repolarization during cardiac muscle cell action potential)
GO:0086064 (cell communication by electrical coupling involved in cardiac conduction)
GO:0090662 (ATP hydrolysis coupled transmembrane transport)
GO:1903416 (response to glycoside)
GO:1903779 (regulation of cardiac conduction)
GO:1990573 (potassium ion import across plasma membrane)
Wikipedia ATPase,_Na%2B/K%2B_transporting,_alpha_1

Target Cross References - Protein

canSAR P05023
Human Protein Atlas ENSG00000163399
IntAct P05023
Open Targets ENSG00000163399
PharmGKB PA62
Reactome R-HSA-5578775 (Ion homeostasis.)
R-HSA-936837 (Ion transport by P-type ATPases.)
UniProt B2RBR6 B7Z2T5 B7Z3U6 F5H3A1 P05023 Q16689 Q6LDM4 Q9UCN1 Q9UJ20 Q9UJ21

Target Cross References - Domain

InterPro IPR001757 (P_typ_ATPase.)
IPR004014 (ATPase_P-typ_cation-transptr_N.)
IPR005775 (P-type_ATPase_IIC.)
IPR006068 (ATPase_P-typ_cation-transptr_C.)
IPR008250 (ATPase_P-typ_transduc_dom_A_sf.)
IPR018303 (ATPase_P-typ_P_site.)
IPR023214 (HAD_sf.)
IPR023298 (ATPase_P-typ_TM_dom_sf.)
IPR023299 (ATPase_P-typ_cyto_dom_N.)
IPR036412 (HAD-like_sf.)
Pfam PF00689 (Cation_ATPase_C)
PF00690 (Cation_ATPase_N)