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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL1805
Preferred Name Serotonin 1f (5-HT1f) receptor
Synonyms 5-HT-1F | 5-HT1F | 5-hydroxytryptamine receptor 1F | HTR1EL | HTR1F | Serotonin receptor 1F
Organism Homo sapiens
Species Group No
Protein Target Classification
  • membrane receptor > family a g protein-coupled receptor > small molecule receptor (family a gpcr) > monoamine receptor > serotonin receptor

Target Components

Component Description Relationship Accession
5-hydroxytryptamine receptor 1F SINGLE PROTEIN P30939

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2096904 Serotonin (5-HT) receptor PROTEIN FAMILY

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL1200521 ALMOTRIPTAN MALATE Serotonin 1f (5-HT1f) receptor agonist 4 FDA
CHEMBL1201003 ELETRIPTAN HYDROBROMIDE Serotonin 1f (5-HT1f) receptor agonist 4 FDA
CHEMBL3039520 LASMIDITAN Serotonin 1f (5-HT1f) receptor agonist 3 PubMed PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000179097
Ensembl ENSG00000179097
GO Cellular Component GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO Molecular Function GO:0004871 (signal transducer activity)
GO:0004930 (G-protein coupled receptor activity)
GO:0004993 (G-protein coupled serotonin receptor activity)
GO:0030594 (neurotransmitter receptor activity)
GO:0051378 (serotonin binding)
GO Biological Process GO:0007165 (signal transduction)
GO:0007186 (G-protein coupled receptor signaling pathway)
GO:0007187 (G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)
GO:0007193 (adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway)
GO:0007268 (chemical synaptic transmission)
GO:0098664 (G-protein coupled serotonin receptor signaling pathway)
Wikipedia 5-HT1F_receptor

Target Cross References - Protein

canSAR P30939
Human Protein Atlas ENSG00000179097
Guide to Pharmacology 5
Open Targets ENSG00000179097
PharmGKB PA29553
Pharos P30939 (Tchem)
Reactome R-HSA-390666 (Serotonin receptors.)
R-HSA-418594 (G alpha (i) signalling events.)
UniProt P30939

Target Cross References - Domain

InterPro IPR000276 (GPCR_Rhodpsn.)
IPR000450 (5HT1F_rcpt.)
IPR002231 (5HT_rcpt.)
IPR017452 (GPCR_Rhodpsn_7TM.)
Pfam PF00001 (7tm_1)