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Target Report Card

Target Name and Classification

Target ID CHEMBL1795088
Target Type SINGLE PROTEIN
Preferred Name Beta-arrestin-1
Synonyms ARR1 | ARRB1 | Arrestin beta-1 | Beta-arrestin-1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • unclassified protein

Target Components

Component Description Relationship Accession
Beta-arrestin-1 SINGLE PROTEIN P49407

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000137486
Ensembl ENSG00000137486
GO Cellular Component GO:0000139 (Golgi membrane)
GO:0000785 (chromatin)
GO:0005622 (intracellular)
GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0005737 (cytoplasm)
GO:0005765 (lysosomal membrane)
GO:0005829 (cytosol)
GO:0005834 (heterotrimeric G-protein complex)
GO:0005886 (plasma membrane)
GO:0005905 (clathrin-coated pit)
GO:0014069 (postsynaptic density)
GO:0016020 (membrane)
GO:0016023 (cytoplasmic, membrane-bounded vesicle)
GO:0016323 (basolateral plasma membrane)
GO:0030659 (cytoplasmic vesicle membrane)
GO:0031143 (pseudopodium)
GO:0031410 (cytoplasmic vesicle)
GO:0042995 (cell projection)
GO:0043197 (dendritic spine)
GO:0045211 (postsynaptic membrane)
GO Molecular Function GO:0004402 (histone acetyltransferase activity)
GO:0004857 (enzyme inhibitor activity)
GO:0005096 (GTPase activator activity)
GO:0005159 (insulin-like growth factor receptor binding)
GO:0005515 (protein binding)
GO:0008134 (transcription factor binding)
GO:0030331 (estrogen receptor binding)
GO:0031434 (mitogen-activated protein kinase kinase binding)
GO:0031625 (ubiquitin protein ligase binding)
GO:0031691 (alpha-1A adrenergic receptor binding)
GO:0031692 (alpha-1B adrenergic receptor binding)
GO:0031701 (angiotensin receptor binding)
GO:0031762 (follicle-stimulating hormone receptor binding)
GO:0031896 (V2 vasopressin receptor binding)
GO:0035612 (AP-2 adaptor complex binding)
GO:0035615 (clathrin adaptor activity)
GO:0043027 (cysteine-type endopeptidase inhibitor activity involved in apoptotic process)
GO:0044212 (transcription regulatory region DNA binding)
GO:0044325 (ion channel binding)
GO:0045309 (protein phosphorylated amino acid binding)
GO:0051219 (phosphoprotein binding)
GO Biological Process GO:0000187 (activation of MAPK activity)
GO:0001933 (negative regulation of protein phosphorylation)
GO:0001934 (positive regulation of protein phosphorylation)
GO:0002031 (G-protein coupled receptor internalization)
GO:0002092 (positive regulation of receptor internalization)
GO:0006351 (transcription, DNA-templated)
GO:0006355 (regulation of transcription, DNA-templated)
GO:0006366 (transcription from RNA polymerase II promoter)
GO:0006810 (transport)
GO:0006897 (endocytosis)
GO:0007165 (signal transduction)
GO:0007186 (G-protein coupled receptor signaling pathway)
GO:0007602 (phototransduction)
GO:0008277 (regulation of G-protein coupled receptor protein signaling pathway)
GO:0009968 (negative regulation of signal transduction)
GO:0015031 (protein transport)
GO:0016567 (protein ubiquitination)
GO:0030168 (platelet activation)
GO:0031397 (negative regulation of protein ubiquitination)
GO:0031398 (positive regulation of protein ubiquitination)
GO:0032088 (negative regulation of NF-kappaB transcription factor activity)
GO:0032092 (positive regulation of protein binding)
GO:0032715 (negative regulation of interleukin-6 production)
GO:0032717 (negative regulation of interleukin-8 production)
GO:0033138 (positive regulation of peptidyl-serine phosphorylation)
GO:0034260 (negative regulation of GTPase activity)
GO:0034393 (positive regulation of smooth muscle cell apoptotic process)
GO:0035025 (positive regulation of Rho protein signal transduction)
GO:0035066 (positive regulation of histone acetylation)
GO:0035774 (positive regulation of insulin secretion involved in cellular response to glucose stimulus)
GO:0036276 (response to antidepressant)
GO:0042699 (follicle-stimulating hormone signaling pathway)
GO:0043149 (stress fiber assembly)
GO:0043154 (negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)
GO:0043161 (proteasome-mediated ubiquitin-dependent protein catabolic process)
GO:0043280 (positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)
GO:0043547 (positive regulation of GTPase activity)
GO:0045944 (positive regulation of transcription from RNA polymerase II promoter)
GO:0070373 (negative regulation of ERK1 and ERK2 cascade)
GO:0070374 (positive regulation of ERK1 and ERK2 cascade)
GO:0090240 (positive regulation of histone H4 acetylation)
Wikipedia Arrestin_beta_1

Target Cross References - Protein

canSAR P49407
Human Protein Atlas ENSG00000137486
IntAct P49407
Open Targets ENSG00000137486
PharmGKB PA59
Reactome R-HSA-2122948 (Activated NOTCH1 Transmits Signal to the Nucleus.)
R-HSA-418555 (G alpha (s) signalling events.)
R-HSA-432720 (Lysosome Vesicle Biogenesis.)
R-HSA-432722 (Golgi Associated Vesicle Biogenesis.)
R-HSA-456926 (Thrombin signalling through proteinase activated receptors (PARs).)
R-HSA-5635838 (Activation of SMO.)
R-HSA-5674135 (MAP2K and MAPK activation.)
R-HSA-5689880 (Ub-specific processing proteases.)
R-HSA-6802946 (Signaling by moderate kinase activity BRAF mutants.)
R-HSA-6802948 (Signaling by high-kinase activity BRAF mutants.)
R-HSA-6802949 (Signaling by RAS mutants.)
R-HSA-6802952 (Signaling by BRAF and RAF fusions.)
R-HSA-6802955 (Paradoxical activation of RAF signaling by kinase inactive BRAF.)
R-HSA-8856825 (Cargo recognition for clathrin-mediated endocytosis.)
R-HSA-8856828 (Clathrin-mediated endocytosis.)
UniProt B6V9G8 O75625 O75630 P49407 Q2PP20 Q9BTK8

Target Cross References - Domain

InterPro IPR000698 (Arrestin.)
IPR011021 (Arrestin-like_N.)
IPR011022 (Arrestin_C-like.)
IPR014752 (Arrestin_C.)
IPR014753 (Arrestin_N.)
IPR014756 (Ig_E-set.)
IPR017864 (Arrestin_CS.)
Pfam PF00339 (Arrestin_N)
PF02752 (Arrestin_C)

Target Cross References - Structure

PDBe 2IV8
CREDO 2IV8
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