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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL1778
Target Type SINGLE PROTEIN
Preferred Name Interleukin-2 receptor alpha chain
Synonyms CD_antigen=CD25 | IL-2 receptor subunit alpha | IL-2-RA | IL-2R subunit alpha | IL2-RA | IL2RA | Interleukin-2 receptor subunit alpha | TAC antigen | p55
Organism Homo sapiens
Species Group No
Protein Target Classification
  • membrane receptor

Target Components

Component Description Relationship Accession
Interleukin-2 receptor subunit alpha SINGLE PROTEIN P01589

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2364167 Interleukin-2 receptor PROTEIN COMPLEX

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000134460
Ensembl ENSG00000134460
GO Cellular Component GO:0016021 (integral to membrane)
GO Molecular Function GO:0004911 (interleukin-2 receptor activity)
GO Biological Process GO:0008283 (cell proliferation)
Wikipedia IL2RA

Target Cross References - Protein

canSAR P01589
CGD Interleukin 2 receptor, alpha, deficiency of
Human Protein Atlas ENSG00000134460
Guide to Pharmacology 1695 (Interleukin-2 receptor α subunit)
PharmGKB PA29828
Reactome REACT_6900 (Signaling in Immune system.)
TIMBAL IL-2
UniProt P01589 Q5W007

Target Cross References - Domain

InterPro IPR000436 (Sushi_SCR_CCP.)
IPR015486 (IL-2_recpt_a.)
IPR016060 (Complement_control_module.)
Pfam PF00084 (Sushi)

Target Cross References - Structure

PDBe 1Z92 2B5I 2ERJ 3IU3 3NFP
CREDO 1Z92 2B5I 2ERJ 3IU3 3NFP
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