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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL1778
Preferred Name Interleukin-2 receptor alpha chain
Synonyms CD_antigen=CD25 | IL-2 receptor subunit alpha | IL-2-RA | IL-2R subunit alpha | IL2-RA | IL2RA | Interleukin-2 receptor subunit alpha | TAC antigen | p55
Organism Homo sapiens
Species Group No
Protein Target Classification
  • membrane receptor

Target Components

Component Description Relationship Accession
Interleukin-2 receptor subunit alpha SINGLE PROTEIN P01589

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2364167 Interleukin-2 receptor PROTEIN COMPLEX

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL2108370 INOLIMOMAB Interleukin-2 receptor alpha chain antagonist 2 PubMed
CHEMBL2109367 LMB-2 Interleukin-2 receptor alpha chain binding agent 2 PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000134460
Ensembl ENSG00000134460
GO Cellular Component GO:0005622 (intracellular)
GO:0005886 (plasma membrane)
GO:0009897 (external side of plasma membrane)
GO:0009986 (cell surface)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO Molecular Function GO:0004911 (interleukin-2 receptor activity)
GO:0005088 (Ras guanyl-nucleotide exchange factor activity)
GO:0008144 (drug binding)
GO:0019976 (interleukin-2 binding)
GO Biological Process GO:0000165 (MAPK cascade)
GO:0002376 (immune system process)
GO:0002437 (inflammatory response to antigenic stimulus)
GO:0002664 (regulation of T cell tolerance induction)
GO:0006915 (apoptotic process)
GO:0006924 (activation-induced cell death of T cells)
GO:0006954 (inflammatory response)
GO:0006955 (immune response)
GO:0007166 (cell surface receptor signaling pathway)
GO:0007219 (Notch signaling pathway)
GO:0008283 (cell proliferation)
GO:0038110 (interleukin-2-mediated signaling pathway)
GO:0042102 (positive regulation of T cell proliferation)
GO:0042104 (positive regulation of activated T cell proliferation)
GO:0042130 (negative regulation of T cell proliferation)
GO:0043029 (T cell homeostasis)
GO:0043547 (positive regulation of GTPase activity)
GO:0045582 (positive regulation of T cell differentiation)
GO:0046013 (regulation of T cell homeostatic proliferation)
GO:0050672 (negative regulation of lymphocyte proliferation)
GO:0050687 (negative regulation of defense response to virus)
GO:0050728 (negative regulation of inflammatory response)
GO:0050777 (negative regulation of immune response)
Wikipedia IL2RA

Target Cross References - Protein

canSAR P01589
CGD Interleukin 2 receptor, alpha, deficiency of
Human Protein Atlas ENSG00000134460
IntAct P01589
Guide to Pharmacology 1695
Open Targets ENSG00000134460
PharmGKB PA29828
Reactome R-HSA-114604 (GPVI-mediated activation cascade.)
R-HSA-392451 (G beta:gamma signalling through PI3Kgamma.)
R-HSA-451927 (Interleukin-2 signaling.)
R-HSA-5673001 (RAF/MAP kinase cascade.)
R-HSA-912526 (Interleukin receptor SHC signaling.)
UniProt P01589 Q5W007

Target Cross References - Domain

InterPro IPR000436 (Sushi_SCR_CCP_dom.)
IPR015486 (IL-2_rcpt_alpha.)
Pfam PF00084 (Sushi)

Target Cross References - Structure

PDBe 1Z92 2B5I 2ERJ 3IU3 3NFP