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Target Report Card

Target Name and Classification

Target ID CHEMBL1770034
Target Type SINGLE PROTEIN
Preferred Name Phosphatidylinositol-5-phosphate 4-kinase type-2 gamma
Synonyms PI(5)P 4-kinase type II gamma | PIP4K2C | PIP4KII-gamma | PIP5K2C | Phosphatidylinositol 5-phosphate 4-kinase type II gamma | Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma SINGLE PROTEIN Q8TBX8

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000166908
Ensembl ENSG00000166908
GO Cellular Component GO:0005737 (cytoplasm)
GO:0005776 (autophagosome)
GO:0005783 (endoplasmic reticulum)
GO:0005829 (cytosol)
GO:0016020 (membrane)
GO:0070062 (extracellular exosome)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0005524 (ATP binding)
GO:0016301 (kinase activity)
GO:0016307 (phosphatidylinositol phosphate kinase activity)
GO:0016308 (1-phosphatidylinositol-4-phosphate 5-kinase activity)
GO:0016309 (1-phosphatidylinositol-5-phosphate 4-kinase activity)
GO:0016740 (transferase activity)
GO:0042802 (identical protein binding)
GO Biological Process GO:0006661 (phosphatidylinositol biosynthetic process)
GO:0010506 (regulation of autophagy)
GO:0014066 (regulation of phosphatidylinositol 3-kinase signaling)
GO:0016310 (phosphorylation)
GO:0046488 (phosphatidylinositol metabolic process)
GO:0046854 (phosphatidylinositol phosphorylation)
GO:2000786 (positive regulation of autophagosome assembly)

Target Cross References - Protein

Human Protein Atlas ENSG00000166908
IntAct Q8TBX8
Guide to Pharmacology 2163
Open Targets ENSG00000166908
PharmGKB PA162399665
Pharos Q8TBX8 (Tdark)
Reactome R-HSA-1660499 (Synthesis of PIPs at the plasma membrane.)
R-HSA-6811555 (PI5P Regulates TP53 Acetylation.)
R-HSA-6811558 (PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling.)
R-HSA-8847453 (Synthesis of PIPs in the nucleus.)
UniProt B2RDL3 B4DM11 B4DY44 Q8TBX8 Q9H6N2

Target Cross References - Domain

InterPro IPR002498 (PInositol-4-P-5-kinase_core.)
IPR023610 (PInositol-4-P-5-kinase.)
IPR027483 (PInositol-4-P-5-kinase_C.)
IPR027484 (PInositol-4-P-5-kinase_N.)
Pfam PF01504 (PIP5K)

Target Cross References - Structure

PDBe 2GK9
CREDO 2GK9
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