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Target Report Card

Target Name and Classification

Target ID CHEMBL1764938
Target Type SINGLE PROTEIN
Preferred Name Annexin A2
Synonyms ANX2 | ANX2L4 | ANXA2 | Annexin A2 | Annexin II | Annexin-2 | CAL1H | Calpactin I heavy chain | Calpactin-1 heavy chain | Chromobindin-8 | LPC2D | Lipocortin II | PAP-IV | Placental anticoagulant protein IV | Protein I | p36
Organism Homo sapiens
Species Group No
Protein Target Classification
  • ion channel > other ion channel > annexin

Target Components

Component Description Relationship Accession
Annexin A2 SINGLE PROTEIN P07355

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2111435 Annexin A2/S100-A10 PROTEIN-PROTEIN INTERACTION

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000182718
Ensembl ENSG00000182718
GO Cellular Component GO:0001726 (ruffle)
GO:0005576 (extracellular region)
GO:0005578 (proteinaceous extracellular matrix)
GO:0005604 (basement membrane)
GO:0005615 (extracellular space)
GO:0005634 (nucleus)
GO:0005737 (cytoplasm)
GO:0005765 (lysosomal membrane)
GO:0005768 (endosome)
GO:0005769 (early endosome)
GO:0005811 (lipid particle)
GO:0005829 (cytosol)
GO:0005886 (plasma membrane)
GO:0005911 (cell-cell junction)
GO:0005938 (cell cortex)
GO:0009986 (cell surface)
GO:0016020 (membrane)
GO:0016323 (basolateral plasma membrane)
GO:0019897 (extrinsic component of plasma membrane)
GO:0030496 (midbody)
GO:0031012 (extracellular matrix)
GO:0031902 (late endosome membrane)
GO:0031982 (vesicle)
GO:0035749 (myelin sheath adaxonal region)
GO:0042383 (sarcolemma)
GO:0042470 (melanosome)
GO:0043220 (Schmidt-Lanterman incisure)
GO:0043234 (protein complex)
GO:0044354 (macropinosome)
GO:0045121 (membrane raft)
GO:0048471 (perinuclear region of cytoplasm)
GO:0070062 (extracellular exosome)
GO:1990667 (PCSK9-AnxA2 complex)
GO Molecular Function GO:0002020 (protease binding)
GO:0003723 (RNA binding)
GO:0004859 (phospholipase inhibitor activity)
GO:0005509 (calcium ion binding)
GO:0005515 (protein binding)
GO:0005544 (calcium-dependent phospholipid binding)
GO:0005546 (phosphatidylinositol-4,5-bisphosphate binding)
GO:0008092 (cytoskeletal protein binding)
GO:0017137 (Rab GTPase binding)
GO:0019834 (phospholipase A2 inhibitor activity)
GO:0030546 (receptor activator activity)
GO:0044548 (S100 protein binding)
GO:0044822 (poly(A) RNA binding)
GO:0048306 (calcium-dependent protein binding)
GO Biological Process GO:0001525 (angiogenesis)
GO:0001765 (membrane raft assembly)
GO:0001934 (positive regulation of protein phosphorylation)
GO:0002091 (negative regulation of receptor internalization)
GO:0006900 (membrane budding)
GO:0007589 (body fluid secretion)
GO:0030199 (collagen fibril organization)
GO:0031340 (positive regulation of vesicle fusion)
GO:0032804 (negative regulation of low-density lipoprotein particle receptor catabolic process)
GO:0036035 (osteoclast development)
GO:0042730 (fibrinolysis)
GO:0043086 (negative regulation of catalytic activity)
GO:0048146 (positive regulation of fibroblast proliferation)
GO:0051099 (positive regulation of binding)
GO:0051290 (protein heterotetramerization)
GO:0072661 (protein targeting to plasma membrane)
GO:0097066 (response to thyroid hormone)
GO:1900121 (negative regulation of receptor binding)
GO:2000273 (positive regulation of receptor activity)
Wikipedia Annexin_A2

Target Cross References - Protein

Human Protein Atlas ENSG00000182718
IntAct P07355
Open Targets ENSG00000182718
PharmGKB PA24827
Reactome R-HSA-445355 (Smooth Muscle Contraction.)
R-HSA-6798695 (Neutrophil degranulation.)
R-HSA-75205 (Dissolution of Fibrin Clot.)
TIMBAL Annexin%20A2
UniProt P07355 Q567R4 Q6N0B3 Q8TBV2 Q96DD5 Q9UDH8

Target Cross References - Domain

InterPro IPR001464 (Annexin.)
IPR002389 (ANX2.)
IPR018252 (Annexin_repeat_CS.)
IPR018502 (Annexin_repeat.)
Pfam PF00191 (Annexin)

Target Cross References - Structure

PDBe 1W7B 1XJL 2HYU 2HYV 2HYW 4DRW 4FTG 4HRH
CREDO 1W7B 1XJL 2HYU 2HYV 2HYW 4DRW 4FTG 4HRH
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