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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL1697667
Target Type SINGLE PROTEIN
Preferred Name AP-2 complex subunit sigma
Synonyms AP-2 complex subunit sigma | Adaptor protein complex AP-2 subunit sigma | Adaptor-related protein complex 2 subunit sigma | Ap17 | Ap2s1 | Claps2 | Clathrin assembly protein 2 sigma small chain | Clathrin coat assembly protein AP17 | Clathrin coat-associated protein AP17 | Plasma membrane adaptor AP-2 17 kDa protein | Sigma-adaptin 3b | Sigma2-adaptin
Organism Rattus norvegicus
Species Group No
Protein Target Classification
  • unclassified protein

Target Components

Component Description Relationship Accession
AP-2 complex subunit sigma SINGLE PROTEIN P62744

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0005794 (Golgi apparatus)
GO:0005886 (plasma membrane)
GO:0005905 (clathrin-coated pit)
GO:0016020 (membrane)
GO:0030117 (membrane coat)
GO:0030121 (AP-1 adaptor complex)
GO:0030122 (AP-2 adaptor complex)
GO Molecular Function GO:0008565 (protein transporter activity)
GO Biological Process GO:0006810 (transport)
GO:0006886 (intracellular protein transport)
GO:0006897 (endocytosis)
GO:0015031 (protein transport)
GO:0016192 (vesicle-mediated transport)

Target Cross References - Protein

IntAct P62744
Reactome R-RNO-171052 (LDL-mediated lipid transport.)
R-RNO-177504 (Retrograde neurotrophin signalling.)
R-RNO-2132295 (MHC class II antigen presentation.)
R-RNO-416993 (Trafficking of GluR2-containing AMPA receptors.)
R-RNO-437239 (Recycling pathway of L1.)
R-RNO-5099900 (WNT5A-dependent internalization of FZD4.)
R-RNO-5140745 (WNT5A-dependent internalization of FZD2, FZD5 and ROR2.)
R-RNO-8856825 (Cargo recognition for clathrin-mediated endocytosis.)
R-RNO-8856828 (Clathrin-mediated endocytosis.)
R-RNO-8866427 (VLDLR internalisation and degradation.)
UniProt P62744 P70626 P97626 Q00380

Target Cross References - Domain

InterPro IPR000804 (Clathrin_sm-chain_CS.)
IPR011012 (Longin-like_dom.)
IPR016635 (AP_complex_ssu.)
IPR022775 (AP_mu_sigma_su.)
IPR027156 (APS2.)
Pfam PF01217 (Clat_adaptor_s)

Target Cross References - Structure

PDBe 4NEE
CREDO 4NEE
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