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Target Report Card

Target Name and Classification

Target ID CHEMBL1697658
Preferred Name Pleiotropic ABC efflux transporter of multiple drugs
Synonyms LEM1 | PDR5 | Pleiotropic ABC efflux transporter of multiple drugs | Pleiotropic drug resistance protein 5 | STS1 | Suppressor of toxicity of sporidesmin | YDR1
Organism Saccharomyces cerevisiae S288c
Species Group No
Protein Target Classification
  • transporter

Target Components

Component Description Relationship Accession
Pleiotropic ABC efflux transporter of multiple drugs SINGLE PROTEIN P33302

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0005886 (plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0005524 (ATP binding)
GO:0008559 (xenobiotic-transporting ATPase activity)
GO:0016887 (ATPase activity)
GO:0042626 (ATPase activity, coupled to transmembrane movement of substances)
GO Biological Process GO:0006855 (drug transmembrane transport)
GO:0015893 (drug transport)
GO:0030003 (cellular cation homeostasis)
GO:0042493 (response to drug)
GO:0042908 (xenobiotic transport)
GO:0046618 (drug export)
GO:0046677 (response to antibiotic)
GO:0046898 (response to cycloheximide)
GO:0055085 (transmembrane transport)

Target Cross References - Protein

IntAct P33302
UniProt D6W2L0 P33302

Target Cross References - Domain

InterPro IPR003439 (ABC_transporter-like.)
IPR003593 (AAA+_ATPase.)
IPR005285 (Drug-R_PDR/CDR.)
IPR010929 (PDR_CDR_ABC.)
IPR013525 (ABC_2_trans.)
IPR017871 (ABC_transporter_CS.)
IPR027417 (P-loop_NTPase.)
IPR029481 (ABC_trans_N.)
IPR034001 (ABCG_PDR_1.)
IPR034003 (ABCG_PDR_2.)
Pfam PF00005 (ABC_tran)
PF01061 (ABC2_membrane)
PF06422 (PDR_CDR)
PF14510 (ABC_trans_N)