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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL1671613
Target Type SINGLE PROTEIN
Preferred Name Type-1 angiotensin II receptor
Synonyms AGTR1 | AT1 | Angiotensin II type-1 receptor | Type-1 angiotensin II receptor
Organism Cavia porcellus
Species Group No
Protein Target Classification
  • membrane receptor > family a g protein-coupled receptor > peptide receptor (family a gpcr) > short peptide receptor (family a gpcr) > angiotensin receptor

Target Components

Component Description Relationship Accession
Type-1 angiotensin II receptor SINGLE PROTEIN Q9WV26

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0005622 (intracellular)
GO:0005829 (cytosol)
GO:0005886 (plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO Molecular Function GO:0001596 (angiotensin type I receptor activity)
GO:0004871 (signal transducer activity)
GO:0004930 (G-protein coupled receptor activity)
GO:0004945 (angiotensin type II receptor activity)
GO:0031711 (bradykinin receptor binding)
GO:0046982 (protein heterodimerization activity)
GO Biological Process GO:0001822 (kidney development)
GO:0007165 (signal transduction)
GO:0007186 (G-protein coupled receptor signaling pathway)
GO:0007204 (positive regulation of cytosolic calcium ion concentration)
GO:0007266 (Rho protein signal transduction)
GO:0010873 (positive regulation of cholesterol esterification)
GO:0019229 (regulation of vasoconstriction)
GO:0019722 (calcium-mediated signaling)
GO:0032270 (positive regulation of cellular protein metabolic process)
GO:0032430 (positive regulation of phospholipase A2 activity)
GO:0038166 (angiotensin-activated signaling pathway)
GO:0051482 (positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway)
GO:0060326 (cell chemotaxis)
GO:0086097 (phospholipase C-activating angiotensin-activated signaling pathway)

Target Cross References - Protein

UniProt Q9WV26

Target Cross References - Domain

InterPro IPR000190 (ATII_AT1_rcpt.)
IPR000248 (ATII_rcpt.)
IPR000276 (GPCR_Rhodpsn.)
IPR017452 (GPCR_Rhodpsn_7TM.)
Pfam PF00001 (7tm_1)
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