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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL1667699
Target Type SINGLE PROTEIN
Preferred Name Isocitrate lyase
Synonyms ICL | Isocitrase | Isocitratase | Isocitrate lyase | icl
Organism Mycobacterium tuberculosis
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Isocitrate lyase SINGLE PROTEIN P9WKK7

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0005829 (cytosol)
GO:0005886 (plasma membrane)
GO Molecular Function GO:0003824 (catalytic activity)
GO:0004451 (isocitrate lyase activity)
GO:0016829 (lyase activity)
GO:0046421 (methylisocitrate lyase activity)
GO:0046872 (metal ion binding)
GO:0046912 (transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer)
GO Biological Process GO:0001101 (response to acid chemical)
GO:0006097 (glyoxylate cycle)
GO:0006099 (tricarboxylic acid cycle)
GO:0006102 (isocitrate metabolic process)
GO:0008152 (metabolic process)
GO:0009405 (pathogenesis)
GO:0010034 (response to acetate)
GO:0019752 (carboxylic acid metabolic process)
GO:0052572 (response to host immune response)
GO:0070542 (response to fatty acid)
GO:0071456 (cellular response to hypoxia)
GO:0075141 (maintenance of symbiont tolerance to host environment)

Target Cross References - Protein

UniProt L0T3N9 O53752 P0A5H3 P9WKK7

Target Cross References - Domain

InterPro IPR006254 (Isocitrate_lyase.)
IPR015813 (Pyrv/PenolPyrv_Kinase-like_dom.)
IPR018523 (Isocitrate_lyase_ph_CS.)
Pfam PF00463 (ICL)

Target Cross References - Structure

PDBe 1F61 1F8I 1F8M 5DQL
CREDO 1F61 1F8I 1F8M 5DQL
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