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Target Report Card

Target Name and Classification

Target ID CHEMBL1649059
Target Type SINGLE PROTEIN
Preferred Name Serine/threonine-protein kinase VRK2
Synonyms Serine/threonine-protein kinase VRK2 | VRK2 | Vaccinia-related kinase 2
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Serine/threonine-protein kinase VRK2 SINGLE PROTEIN Q86Y07

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000028116
Ensembl ENSG00000028116
GO Cellular Component GO:0005634 (nucleus)
GO:0005737 (cytoplasm)
GO:0005739 (mitochondrion)
GO:0005783 (endoplasmic reticulum)
GO:0005789 (endoplasmic reticulum membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0031966 (mitochondrial membrane)
GO:0032991 (macromolecular complex)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0004672 (protein kinase activity)
GO:0004674 (protein serine/threonine kinase activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO:0019901 (protein kinase binding)
GO:0019904 (protein domain specific binding)
GO Biological Process GO:0006468 (protein phosphorylation)
GO:0008360 (regulation of cell shape)
GO:0016032 (viral process)
GO:0016310 (phosphorylation)
GO:0018105 (peptidyl-serine phosphorylation)
GO:0034599 (cellular response to oxidative stress)
GO:0043408 (regulation of MAPK cascade)
GO:0046777 (protein autophosphorylation)
GO:2000659 (regulation of interleukin-1-mediated signaling pathway)
Wikipedia VRK2

Target Cross References - Protein

Human Protein Atlas ENSG00000028116
IntAct Q86Y07
Guide to Pharmacology 2276
Open Targets ENSG00000028116
PharmGKB PA37331
Pharos Q86Y07 (Tbio)
Reactome R-HSA-2993913 (Clearance of Nuclear Envelope Membranes from Chromatin.)
R-HSA-2995383 (Initiation of Nuclear Envelope Reformation.)
UniProt B4DKL0 D6W5D4 D6W5D6 Q49AK9 Q53EU9 Q53S39 Q53S77 Q53TU1 Q86Y07 Q86Y08 Q86Y09 Q86Y10 Q86Y11 Q86Y12 Q8IXI5 Q99987

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_dom.)
IPR008271 (Ser/Thr_kinase_AS.)
IPR011009 (Kinase-like_dom_sf.)
Pfam PF00069 (Pkinase)

Target Cross References - Structure

PDBe 2V62 5UU1
CREDO 2V62 5UU1
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