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Target Report Card

Target Name and Classification

Target ID CHEMBL1628477
Preferred Name Amiloride-sensitive cation channel 2, neuronal
Synonyms ACCN2 | ASIC1 | ASIC1 | Acid-sensing ion channel 1 | Amiloride-sensitive cation channel 2, neuronal | BNAC2 | BNaC2 | Brain sodium channel 2
Organism Homo sapiens
Species Group No
Protein Target Classification
  • ion channel > ligand-gated ion channel > acid-sensing ion channel

Target Components

Component Description Relationship Accession
Acid-sensing ion channel 1 SINGLE PROTEIN P78348

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000110881
Ensembl ENSG00000110881
GO Cellular Component GO:0005794 (Golgi apparatus)
GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0009986 (cell surface)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0045202 (synapse)
GO Molecular Function GO:0005216 (ion channel activity)
GO:0005261 (cation channel activity)
GO:0005272 (sodium channel activity)
GO:0005515 (protein binding)
GO:0015280 (ligand-gated sodium channel activity)
GO:0022839 (ion gated channel activity)
GO:0044736 (acid-sensing ion channel activity)
GO Biological Process GO:0001662 (behavioral fear response)
GO:0001975 (response to amphetamine)
GO:0006811 (ion transport)
GO:0006812 (cation transport)
GO:0006814 (sodium ion transport)
GO:0006816 (calcium ion transport)
GO:0007165 (signal transduction)
GO:0007613 (memory)
GO:0008306 (associative learning)
GO:0009268 (response to pH)
GO:0010447 (response to acidic pH)
GO:0034220 (ion transmembrane transport)
GO:0035725 (sodium ion transmembrane transport)
GO:0042391 (regulation of membrane potential)
GO:0046929 (negative regulation of neurotransmitter secretion)
GO:0050915 (sensory perception of sour taste)
GO:0070207 (protein homotrimerization)
GO:0070588 (calcium ion transmembrane transport)
GO:0071467 (cellular response to pH)
Wikipedia ACCN2

Target Cross References - Protein

Human Protein Atlas ENSG00000110881
IntAct P78348
Guide to Pharmacology 684
Open Targets ENSG00000110881
PharmGKB PA24434
Pharos P78348 (Tchem)
Reactome R-HSA-2672351 (Stimuli-sensing channels.)
UniProt A3KN86 E5KBL7 P78348 P78349 Q96CV2

Target Cross References - Domain

InterPro IPR001873 (ENaC.)
IPR004724 (ENaC_chordates.)
IPR020903 (ENaC_CS.)
Pfam PF00858 (ASC)