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Target Report Card

Target Name and Classification

Target ID CHEMBL1255161
Preferred Name Proline-rich AKT1 substrate 1
Synonyms 40 kDa proline-rich AKT substrate | AKT1S1 | ECO:0000303|PubMed:16174443} | PRAS40 | Proline-rich AKT1 substrate 1 | {ECO:0000303|PubMed:12524439
Organism Homo sapiens
Species Group No
Protein Target Classification
  • unclassified protein

Target Components

Component Description Relationship Accession
Proline-rich AKT1 substrate 1 SINGLE PROTEIN Q96B36

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000204673
Ensembl ENSG00000204673
GO Cellular Component GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0005737 (cytoplasm)
GO:0005829 (cytosol)
GO:0031931 (TORC1 complex)
GO:0043234 (protein complex)
GO Molecular Function GO:0005515 (protein binding)
GO Biological Process GO:0006469 (negative regulation of protein kinase activity)
GO:0032007 (negative regulation of TOR signaling)
GO:0043523 (regulation of neuron apoptotic process)
GO:0045792 (negative regulation of cell size)
GO:0048011 (neurotrophin TRK receptor signaling pathway)
GO:1900034 (regulation of cellular response to heat)
Wikipedia AKT1S1

Target Cross References - Protein

Human Protein Atlas ENSG00000204673
IntAct Q96B36
Open Targets ENSG00000204673
PharmGKB PA134943587
Reactome R-HSA-165159 (mTOR signalling.)
R-HSA-166208 (mTORC1-mediated signalling.)
R-HSA-198323 (AKT phosphorylates targets in the cytosol.)
R-HSA-3371571 (HSF1-dependent transactivation.)
R-HSA-5674400 (Constitutive Signaling by AKT1 E17K in Cancer.)
UniProt A8MTQ1 B2RE93 J3KPM3 Q96B36 Q96BI4 Q96IK7 Q96NG2 Q9BWR5

Target Cross References - Domain

InterPro IPR026682 (AKT1S1.)
Pfam PF15798 (PRAS)