ChEMBL logo

ChEMBL

spacer
ChEMBL Statistics
  Loading Statistics...
spacer

Target Report Card

Target Name and Classification

Target ID CHEMBL1250407
Target Type SINGLE PROTEIN
Preferred Name Bradykinin B1 receptor
Synonyms B1 bradykinin receptor | B1R | BK-1 receptor | Bdkrb | Bdkrb1
Organism Mus musculus
Species Group No
Protein Target Classification
  • membrane receptor > family a g protein-coupled receptor > peptide receptor (family a gpcr) > short peptide receptor (family a gpcr) > bradykinin receptor

Target Components

Component Description Relationship Accession
B1 bradykinin receptor SINGLE PROTEIN Q61125

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0005886 (plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0043005 (neuron projection)
GO Molecular Function GO:0004871 (signal transducer activity)
GO:0004930 (G-protein coupled receptor activity)
GO:0004947 (bradykinin receptor activity)
GO:0042277 (peptide binding)
GO Biological Process GO:0001933 (negative regulation of protein phosphorylation)
GO:0002687 (positive regulation of leukocyte migration)
GO:0006950 (response to stress)
GO:0006954 (inflammatory response)
GO:0007165 (signal transduction)
GO:0007186 (G-protein coupled receptor signaling pathway)
GO:0007205 (protein kinase C-activating G-protein coupled receptor signaling pathway)
GO:0009612 (response to mechanical stimulus)
GO:0016477 (cell migration)
GO:0019233 (sensory perception of pain)
GO:0030308 (negative regulation of cell growth)
GO:0032496 (response to lipopolysaccharide)
GO:0045776 (negative regulation of blood pressure)
GO:0051281 (positive regulation of release of sequestered calcium ion into cytosol)

Target Cross References - Protein

Guide to Pharmacology 41
Reactome R-MMU-375276 (Peptide ligand-binding receptors.)
R-MMU-416476 (G alpha (q) signalling events.)
R-MMU-418594 (G alpha (i) signalling events.)
UniProt Q61125 Q9Z1F4

Target Cross References - Domain

InterPro IPR000276 (GPCR_Rhodpsn.)
IPR000496 (Brdyknn_rcpt.)
IPR001186 (Brdyknn_1_rcpt.)
IPR017452 (GPCR_Rhodpsn_7TM.)
Pfam PF00001 (7tm_1)
spacer
spacer