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Target Report Card

Target Name and Classification

Target ID CHEMBL1250407
Preferred Name Bradykinin B1 receptor
Synonyms B1 bradykinin receptor | B1R | BK-1 receptor | Bdkrb | Bdkrb1
Organism Mus musculus
Species Group No
Protein Target Classification
  • membrane receptor > family a g protein-coupled receptor > peptide receptor (family a gpcr) > short peptide receptor (family a gpcr) > bradykinin receptor

Target Components

Component Description Relationship Accession
B1 bradykinin receptor SINGLE PROTEIN Q61125

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0005886 (plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0043005 (neuron projection)
GO Molecular Function GO:0004871 (signal transducer activity)
GO:0004930 (G-protein coupled receptor activity)
GO:0004947 (bradykinin receptor activity)
GO:0042277 (peptide binding)
GO Biological Process GO:0001933 (negative regulation of protein phosphorylation)
GO:0002687 (positive regulation of leukocyte migration)
GO:0006950 (response to stress)
GO:0006954 (inflammatory response)
GO:0007165 (signal transduction)
GO:0007186 (G-protein coupled receptor signaling pathway)
GO:0007205 (protein kinase C-activating G-protein coupled receptor signaling pathway)
GO:0009612 (response to mechanical stimulus)
GO:0016477 (cell migration)
GO:0019233 (sensory perception of pain)
GO:0030308 (negative regulation of cell growth)
GO:0032496 (response to lipopolysaccharide)
GO:0045776 (negative regulation of blood pressure)
GO:0051281 (positive regulation of release of sequestered calcium ion into cytosol)

Target Cross References - Protein

Guide to Pharmacology 41
Reactome R-MMU-375276 (Peptide ligand-binding receptors.)
R-MMU-416476 (G alpha (q) signalling events.)
R-MMU-418594 (G alpha (i) signalling events.)
UniProt Q61125 Q9Z1F4

Target Cross References - Domain

InterPro IPR000276 (GPCR_Rhodpsn.)
IPR000496 (Brdyknn_rcpt.)
IPR001186 (Brdyknn_1_rcpt.)
IPR017452 (GPCR_Rhodpsn_7TM.)
Pfam PF00001 (7tm_1)