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Target Report Card

Target Name and Classification

Target ID CHEMBL1250375
Preferred Name NADPH oxidase 4
Synonyms KOX-1 | Kidney oxidase-1 | Kidney superoxide-producing NADPH oxidase | NADPH oxidase 4 | NOX4 | RENOX | Renal NAD(P)H-oxidase
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000086991
Ensembl ENSG00000086991
GO Cellular Component GO:0001725 (stress fiber)
GO:0005634 (nucleus)
GO:0005730 (nucleolus)
GO:0005739 (mitochondrion)
GO:0005783 (endoplasmic reticulum)
GO:0005789 (endoplasmic reticulum membrane)
GO:0005886 (plasma membrane)
GO:0005925 (focal adhesion)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0016324 (apical plasma membrane)
GO:0030054 (cell junction)
GO:0043020 (NADPH oxidase complex)
GO:0048471 (perinuclear region of cytoplasm)
GO:0071944 (cell periphery)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0005515 (protein binding)
GO:0009055 (electron carrier activity)
GO:0016174 (NAD(P)H oxidase activity)
GO:0016175 (superoxide-generating NADPH oxidase activity)
GO:0016491 (oxidoreductase activity)
GO:0019826 (oxygen sensor activity)
GO:0020037 (heme binding)
GO:0050660 (flavin adenine dinucleotide binding)
GO:0050664 (oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor)
GO:0072341 (modified amino acid binding)
GO Biological Process GO:0000902 (cell morphogenesis)
GO:0001666 (response to hypoxia)
GO:0006801 (superoxide metabolic process)
GO:0006954 (inflammatory response)
GO:0007568 (aging)
GO:0007569 (cell aging)
GO:0008285 (negative regulation of cell proliferation)
GO:0010467 (gene expression)
GO:0014911 (positive regulation of smooth muscle cell migration)
GO:0022900 (electron transport chain)
GO:0034599 (cellular response to oxidative stress)
GO:0042554 (superoxide anion generation)
GO:0043065 (positive regulation of apoptotic process)
GO:0043406 (positive regulation of MAP kinase activity)
GO:0045453 (bone resorption)
GO:0050667 (homocysteine metabolic process)
GO:0051496 (positive regulation of stress fiber assembly)
GO:0051897 (positive regulation of protein kinase B signaling)
GO:0055007 (cardiac muscle cell differentiation)
GO:0055114 (oxidation-reduction process)
GO:0070374 (positive regulation of ERK1 and ERK2 cascade)
GO:0071320 (cellular response to cAMP)
GO:0071333 (cellular response to glucose stimulus)
GO:0071480 (cellular response to gamma radiation)
GO:0071560 (cellular response to transforming growth factor beta stimulus)
GO:0072593 (reactive oxygen species metabolic process)
GO:2000379 (positive regulation of reactive oxygen species metabolic process)
GO:2000573 (positive regulation of DNA biosynthetic process)
Wikipedia NOX4

Target Cross References - Protein

Human Protein Atlas ENSG00000086991
IntAct Q9NPH5
Open Targets ENSG00000086991
PharmGKB PA31692
Reactome R-HSA-3299685 (Detoxification of Reactive Oxygen Species.)
UniProt A8K715 B7Z520 E7EMD7 Q5K3R4 Q5K3R5 Q5K3R6 Q5K3R8 Q7Z7G3 Q86V92 Q9NPH5

Target Cross References - Domain

InterPro IPR000778 (Cyt_b245_heavy_chain.)
IPR013112 (FAD-bd_8.)
IPR013121 (Fe_red_NAD-bd_6.)
IPR013130 (Fe3_Rdtase_TM_dom.)
IPR017927 (Fd_Rdtase_FAD-bd.)
IPR017938 (Riboflavin_synthase-like_b-brl.)
Pfam PF01794 (Ferric_reduct)
PF08022 (FAD_binding_8)
PF08030 (NAD_binding_6)