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Target Report Card

Target Name and Classification

Target ID CHEMBL1075310
Preferred Name Transient receptor potential cation channel subfamily A member 1
Synonyms Anktm1 | Ankyrin-like with transmembrane domains protein 1 | Transient receptor potential cation channel subfamily A member 1 | Trpa1
Organism Mus musculus
Species Group No
Protein Target Classification
  • ion channel > voltage-gated ion channel > transient receptor potential channel

Target Components

Component Description Relationship Accession
Transient receptor potential cation channel subfamily A member 1 SINGLE PROTEIN Q8BLA8

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0016324 (apical plasma membrane)
GO:0030424 (axon)
GO:0032421 (stereocilium bundle)
GO Molecular Function GO:0005216 (ion channel activity)
GO:0005245 (voltage-gated calcium channel activity)
GO:0005262 (calcium channel activity)
GO:0005515 (protein binding)
GO:0015267 (channel activity)
GO:0015278 (calcium-release channel activity)
GO:0042802 (identical protein binding)
GO:0097604 (temperature-gated cation channel activity)
GO:1990760 (osmolarity-sensing cation channel activity)
GO Biological Process GO:0006811 (ion transport)
GO:0006816 (calcium ion transport)
GO:0007166 (cell surface receptor signaling pathway)
GO:0009409 (response to cold)
GO:0010033 (response to organic substance)
GO:0014070 (response to organic cyclic compound)
GO:0014832 (urinary bladder smooth muscle contraction)
GO:0019233 (sensory perception of pain)
GO:0034220 (ion transmembrane transport)
GO:0034605 (cellular response to heat)
GO:0035774 (positive regulation of insulin secretion involved in cellular response to glucose stimulus)
GO:0042493 (response to drug)
GO:0042542 (response to hydrogen peroxide)
GO:0048265 (response to pain)
GO:0050896 (response to stimulus)
GO:0050955 (thermoception)
GO:0050966 (detection of mechanical stimulus involved in sensory perception of pain)
GO:0050968 (detection of chemical stimulus involved in sensory perception of pain)
GO:0051209 (release of sequestered calcium ion into cytosol)
GO:0051289 (protein homotetramerization)
GO:0055085 (transmembrane transport)
GO:0070417 (cellular response to cold)
GO:0070588 (calcium ion transmembrane transport)
GO:0071244 (cellular response to carbon dioxide)
GO:0097553 (calcium ion transmembrane import into cytosol)
GO:0098908 (regulation of neuronal action potential)
GO:1903522 (regulation of blood circulation)
GO:1903793 (positive regulation of anion transport)
GO:1904058 (positive regulation of sensory perception of pain)

Target Cross References - Protein

Guide to Pharmacology 485
Reactome R-MMU-3295583 (TRP channels.)
UniProt Q0VBN5 Q8BLA8

Target Cross References - Domain

InterPro IPR002110 (Ankyrin_rpt.)
IPR005821 (Ion_trans_dom.)
IPR020683 (Ankyrin_rpt-contain_dom.)
IPR030288 (TRPA1/painless.)
IPR036770 (Ankyrin_rpt-contain_sf.)
Pfam PF00520 (Ion_trans)
PF12796 (Ank_2)