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Target Report Card

Target Name and Classification

Target ID CHEMBL1075275
Preferred Name Serine/threonine-protein kinase 12
Synonyms ARK-2 | Aik2 | Aim1 | Airk2 | Ark2 | Aurkb | Aurora 1 | Aurora kinase B | Aurora- and IPL1-like midbody-associated protein 1 | Aurora-related kinase 2 | Aurora/IPL1-related kinase 2 | STK-1 | Serine/threonine-protein kinase 12 | Serine/threonine-protein kinase 5 | Serine/threonine-protein kinase aurora-B | Stk1 | Stk12 | Stk5
Organism Mus musculus
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > other protein kinase group > other protein kinase aur family

Target Components

Component Description Relationship Accession
Aurora kinase B SINGLE PROTEIN O70126

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0000775 (chromosome, centromeric region)
GO:0000776 (kinetochore)
GO:0000779 (condensed chromosome, centromeric region)
GO:0000780 (condensed nuclear chromosome, centromeric region)
GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0005694 (chromosome)
GO:0005737 (cytoplasm)
GO:0005819 (spindle)
GO:0005856 (cytoskeleton)
GO:0005876 (spindle microtubule)
GO:0010369 (chromocenter)
GO:0030496 (midbody)
GO:0031616 (spindle pole centrosome)
GO:0032133 (chromosome passenger complex)
GO:0045171 (intercellular bridge)
GO:0051233 (spindle midzone)
GO:0097431 (mitotic spindle pole)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0004672 (protein kinase activity)
GO:0004674 (protein serine/threonine kinase activity)
GO:0004712 (protein serine/threonine/tyrosine kinase activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO:0035174 (histone serine kinase activity)
GO:0046872 (metal ion binding)
GO Biological Process GO:0000122 (negative regulation of transcription from RNA polymerase II promoter)
GO:0002903 (negative regulation of B cell apoptotic process)
GO:0006468 (protein phosphorylation)
GO:0007049 (cell cycle)
GO:0007051 (spindle organization)
GO:0007052 (mitotic spindle organization)
GO:0007067 (mitotic nuclear division)
GO:0007568 (aging)
GO:0008283 (cell proliferation)
GO:0009838 (abscission)
GO:0016310 (phosphorylation)
GO:0031577 (spindle checkpoint)
GO:0032091 (negative regulation of protein binding)
GO:0032212 (positive regulation of telomere maintenance via telomerase)
GO:0032465 (regulation of cytokinesis)
GO:0032466 (negative regulation of cytokinesis)
GO:0032467 (positive regulation of cytokinesis)
GO:0034501 (protein localization to kinetochore)
GO:0034644 (cellular response to UV)
GO:0036089 (cleavage furrow formation)
GO:0043988 (histone H3-S28 phosphorylation)
GO:0051256 (mitotic spindle midzone assembly)
GO:0051301 (cell division)
GO:0051973 (positive regulation of telomerase activity)
GO:1904355 (positive regulation of telomere capping)

Target Cross References - Protein

IntAct O70126
Reactome R-MMU-174178 (APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1.)
R-MMU-2467813 (Separation of Sister Chromatids.)
R-MMU-2500257 (Resolution of Sister Chromatid Cohesion.)
R-MMU-4615885 (SUMOylation of DNA replication proteins.)
R-MMU-5663220 (RHO GTPases Activate Formins.)
R-MMU-6804756 (Regulation of TP53 Activity through Phosphorylation.)
UniProt O70126 Q61882 Q8C6C1

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_dom.)
IPR008271 (Ser/Thr_kinase_AS.)
IPR011009 (Kinase-like_dom.)
IPR017441 (Protein_kinase_ATP_BS.)
IPR028772 (AURKB.)
IPR030616 (Aur.)
Pfam PF00069 (Pkinase)