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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL1075270
Target Type SINGLE PROTEIN
Preferred Name Aldo-keto reductase family 1 member C21
Synonyms 17-alpha-HSD | 17-alpha-hydroxysteroid dehydrogenase | 3(or 17)-alpha-hydroxysteroid dehydrogenase | 3-alpha-hydroxysteroid dehydrogenase | Akr1c21 | Aldo-keto reductase family 1 member C21 | DD1 | DD3 | Dihydrodiol dehydrogenase type 1 | Dihydrodiol dehydrogenase type 3
Organism Mus musculus
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Aldo-keto reductase family 1 member C21 SINGLE PROTEIN Q91WR5

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0005737 (cytoplasm)
GO:0005829 (cytosol)
GO:0070062 (extracellular exosome)
GO Molecular Function GO:0004032 (alditol:NADP+ 1-oxidoreductase activity)
GO:0004033 (aldo-keto reductase (NADP) activity)
GO:0016491 (oxidoreductase activity)
GO:0016655 (oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor)
GO:0018636 (phenanthrene 9,10-monooxygenase activity)
GO:0031406 (carboxylic acid binding)
GO:0032052 (bile acid binding)
GO:0033764 (steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor)
GO:0047023 (androsterone dehydrogenase activity)
GO:0047042 (androsterone dehydrogenase (B-specific) activity)
GO:0047086 (ketosteroid monooxygenase activity)
GO:0047115 (trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity)
GO Biological Process GO:0006629 (lipid metabolic process)
GO:0006694 (steroid biosynthetic process)
GO:0008202 (steroid metabolic process)
GO:0055114 (oxidation-reduction process)

Target Cross References - Protein

canSAR Q91WR5
UniProt Q6P8V0 Q91WR5 Q9CX32

Target Cross References - Domain

InterPro IPR018170 (Aldo/ket_reductase_CS.)
IPR020471 (Aldo/keto_reductase.)
IPR023210 (NADP_OxRdtase_dom.)
Pfam PF00248 (Aldo_ket_red)

Target Cross References - Structure

PDBe 2HE5 2HE8 2HEJ 2IPF 2IPG 2P5N 3CV6 3FJN
CREDO 2HE5 2HE8 2HEJ 2IPF 2IPG 2P5N 3CV6 3FJN
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