ChEMBL logo

ChEMBL

spacer
ChEMBL Statistics
  Loading Statistics...
spacer

Target Report Card

Target Name and Classification

Target ID CHEMBL1075270
Target Type SINGLE PROTEIN
Preferred Name Aldo-keto reductase family 1 member C21
Synonyms 17-alpha-HSD | 17-alpha-hydroxysteroid dehydrogenase | 3(or 17)-alpha-hydroxysteroid dehydrogenase | 3-alpha-hydroxysteroid dehydrogenase | Akr1c21 | Aldo-keto reductase family 1 member C21 | DD1 | DD3 | Dihydrodiol dehydrogenase type 1 | Dihydrodiol dehydrogenase type 3
Organism Mus musculus
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Aldo-keto reductase family 1 member C21 SINGLE PROTEIN Q91WR5

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0005737 (cytoplasm)
GO:0005829 (cytosol)
GO Molecular Function GO:0004032 (alditol:NADP+ 1-oxidoreductase activity)
GO:0004033 (aldo-keto reductase (NADP) activity)
GO:0005496 (steroid binding)
GO:0016491 (oxidoreductase activity)
GO:0016655 (oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor)
GO:0018636 (phenanthrene 9,10-monooxygenase activity)
GO:0031406 (carboxylic acid binding)
GO:0032052 (bile acid binding)
GO:0033764 (steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor)
GO:0047023 (androsterone dehydrogenase activity)
GO:0047024 (5alpha-androstane-3beta,17beta-diol dehydrogenase activity)
GO:0047042 (androsterone dehydrogenase (B-specific) activity)
GO:0047086 (ketosteroid monooxygenase activity)
GO:0047115 (trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity)
GO:0070401 (NADP+ binding)
GO:0070402 (NADPH binding)
GO:0072555 (17-beta-ketosteroid reductase activity)
GO:0072582 (17-beta-hydroxysteroid dehydrogenase (NADP+) activity)
GO:1902121 (lithocholic acid binding)
GO Biological Process GO:0006629 (lipid metabolic process)
GO:0006694 (steroid biosynthetic process)
GO:0008202 (steroid metabolic process)
GO:0055114 (oxidation-reduction process)

Target Cross References - Protein

canSAR Q91WR5
Reactome R-MMU-193368 (Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol.)
R-MMU-193775 (Synthesis of bile acids and bile salts via 24-hydroxycholesterol.)
R-MMU-193807 (Synthesis of bile acids and bile salts via 27-hydroxycholesterol.)
R-MMU-2162123 (Synthesis of Prostaglandins (PG) and Thromboxanes (TX).)
R-MMU-5365859 (RA biosynthesis pathway.)
R-MMU-975634 (Retinoid metabolism and transport.)
UniProt Q6P8V0 Q91WR5 Q9CX32

Target Cross References - Domain

InterPro IPR018170 (Aldo/ket_reductase_CS.)
IPR020471 (Aldo/keto_reductase.)
IPR023210 (NADP_OxRdtase_dom.)
IPR036812 (NADP_OxRdtase_dom_sf.)
Pfam PF00248 (Aldo_ket_red)

Target Cross References - Structure

PDBe 2HE5 2HE8 2HEJ 2IPF 2IPG 2P5N 3CV6 3FJN
CREDO 2HE5 2HE8 2HEJ 2IPF 2IPG 2P5N 3CV6 3FJN
spacer
spacer