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Target Report Card

Target Name and Classification

Target ID CHEMBL1075269
Preferred Name Adenosine A3 receptor
Synonyms A3AR | Adenosine receptor A3 | Adora3 | Gpcr2
Organism Mus musculus
Species Group No
Protein Target Classification
  • membrane receptor > family a g protein-coupled receptor > small molecule receptor (family a gpcr) > nucleotide-like receptor (family a gpcr) > adenosine receptor

Target Components

Component Description Relationship Accession
Adenosine receptor A3 SINGLE PROTEIN Q61618

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0005622 (intracellular)
GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0042629 (mast cell granule)
GO Molecular Function GO:0001609 (G-protein coupled adenosine receptor activity)
GO:0004871 (signal transducer activity)
GO:0004930 (G-protein coupled receptor activity)
GO Biological Process GO:0001973 (adenosine receptor signaling pathway)
GO:0002553 (histamine secretion by mast cell)
GO:0002687 (positive regulation of leukocyte migration)
GO:0007165 (signal transduction)
GO:0007186 (G-protein coupled receptor signaling pathway)
GO:0008285 (negative regulation of cell proliferation)
GO:0014068 (positive regulation of phosphatidylinositol 3-kinase signaling)
GO:0030336 (negative regulation of cell migration)
GO:0032088 (negative regulation of NF-kappaB transcription factor activity)
GO:0043306 (positive regulation of mast cell degranulation)
GO:0050729 (positive regulation of inflammatory response)
GO:0050850 (positive regulation of calcium-mediated signaling)
GO:0070257 (positive regulation of mucus secretion)

Target Cross References - Protein

canSAR Q61618
Guide to Pharmacology 21
MICAD NBK23295 (Adenosine A3 receptors)
UniProt Q61618 Q9R202

Target Cross References - Domain

InterPro IPR000276 (GPCR_Rhodpsn.)
IPR000466 (Adeno_A3_rcpt.)
IPR001634 (Adenosn_rcpt.)
IPR017452 (GPCR_Rhodpsn_7TM.)
Pfam PF00001 (7tm_1)