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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL1075257
Target Type SINGLE PROTEIN
Preferred Name Large T antigen
Synonyms LT | LT-AG | Large T antigen
Organism Simian virus 40
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Large T antigen SINGLE PROTEIN P03070

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0042025 (host cell nucleus)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0003677 (DNA binding)
GO:0003688 (DNA replication origin binding)
GO:0003690 (double-stranded DNA binding)
GO:0003697 (single-stranded DNA binding)
GO:0004386 (helicase activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0016787 (hydrolase activity)
GO:0046872 (metal ion binding)
GO Biological Process GO:0006260 (DNA replication)
GO:0006268 (DNA unwinding involved in DNA replication)
GO:0006351 (transcription, DNA-templated)
GO:0006355 (regulation of transcription, DNA-templated)
GO:0016032 (viral process)
GO:0030683 (evasion or tolerance by virus of host immune response)
GO:0039502 (suppression by virus of host type I interferon-mediated signaling pathway)
GO:0039503 (suppression by virus of host innate immune response)
GO:0039576 (suppression by virus of host JAK1 activity)
GO:0039645 (modulation by virus of host G1/S transition checkpoint)
GO:0039648 (modulation by virus of host protein ubiquitination)
GO:0039649 (modulation by virus of host ubiquitin-protein ligase activity)
GO:0039686 (bidirectional double-stranded viral DNA replication)
GO:0039693 (viral DNA genome replication)
GO:0060153 (modulation by virus of host cell cycle)

Target Cross References - Protein

canSAR P03070
IntAct P03070
UniProt P03070

Target Cross References - Domain

InterPro IPR001623 (DnaJ_domain.)
IPR003133 (T_Ag_DNA-bd.)
IPR010932 (Lg_T_Ag_Polyomavir_C.)
IPR014015 (Helicase_SF3_DNA-vir.)
IPR016392 (Lg_T_Ag_polyomavir.)
IPR017910 (Znf_lg_T-Ag_D1-typ.)
IPR027417 (P-loop_NTPase.)
Pfam PF02217 (T_Ag_DNA_bind)
PF06431 (Polyoma_lg_T_C)

Target Cross References - Structure

PDBe 1EJL 1GH6 1N25 1Q1S 1Q1T 1SVL 1SVM 1SVO 2FUF 2H1L 2IF9 2IPR 2ITJ 2ITL 2NL8 2NTC 3QK2 3QN2 4E2I 4FGN 4GDF 4RXH 5D9I 5TCT
CREDO 1EJL 1GH6 1N25 1Q1S 1Q1T 1SVL 1SVM 1SVO 2FUF 2H1L 2IF9 2IPR 2ITJ 2ITL 2NL8 2NTC 3QK2 3QN2 4E2I 4FGN 4GDF 4RXH 5D9I 5TCT
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