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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL1075214
Target Type SINGLE PROTEIN
Preferred Name 5'-nucleotidase
Synonyms 5'-NT | 5'-nucleotidase | CD_antigen=CD73 | Ecto-5'-nucleotidase | Nt5 | Nt5e | Nte
Organism Rattus norvegicus
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
5'-nucleotidase SINGLE PROTEIN P21588

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0005886 (plasma membrane)
GO:0009986 (cell surface)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0031225 (anchored component of membrane)
GO:0097060 (synaptic membrane)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0008198 (ferrous iron binding)
GO:0008253 (5'-nucleotidase activity)
GO:0016787 (hydrolase activity)
GO:0016788 (hydrolase activity, acting on ester bonds)
GO:0046872 (metal ion binding)
GO Biological Process GO:0006164 (purine nucleotide biosynthetic process)
GO:0006196 (AMP catabolic process)
GO:0007420 (brain development)
GO:0009166 (nucleotide catabolic process)
GO:0010044 (response to aluminum ion)
GO:0016311 (dephosphorylation)
GO:0046085 (adenosine metabolic process)
GO:0046889 (positive regulation of lipid biosynthetic process)

Target Cross References - Protein

canSAR P21588
Guide to Pharmacology 1232
UniProt P21588

Target Cross References - Domain

InterPro IPR004843 (Calcineurin-like_PHP_ApaH.)
IPR006146 (5'-Nucleotdase_CS.)
IPR006179 (5_nucleotidase/apyrase.)
IPR008334 (5'-Nucleotdase_C.)
IPR029052 (Metallo-depent_PP-like.)
Pfam PF00149 (Metallophos)
PF02872 (5_nucleotid_C)
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