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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL1075166
Target Type SINGLE PROTEIN
Preferred Name Beta-adrenergic receptor kinase 2
Synonyms ADRBK2 | BARK2 | Beta-ARK-2 | Beta-adrenergic receptor kinase 2 | G-protein-coupled receptor kinase 3 | GRK3
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > agc protein kinase group > agc protein kinase grk family > agc protein kinase bark subfamily

Target Components

Component Description Relationship Accession
Beta-adrenergic receptor kinase 2 SINGLE PROTEIN P35626

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000100077
Ensembl ENSG00000100077
GO Cellular Component GO:0005886 (plasma membrane)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0004672 (protein kinase activity)
GO:0004674 (protein serine/threonine kinase activity)
GO:0004703 (G-protein coupled receptor kinase activity)
GO:0005524 (ATP binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO:0047696 (beta-adrenergic receptor kinase activity)
GO Biological Process GO:0006468 (protein phosphorylation)
GO:0007165 (signal transduction)
GO:0016310 (phosphorylation)
GO:0031623 (receptor internalization)
Wikipedia Beta_adrenergic_receptor_kinase-2

Target Cross References - Protein

canSAR P35626
Human Protein Atlas ENSG00000100077
IntAct P35626
Guide to Pharmacology 1467
Open Targets ENSG00000100077
PharmGKB PA41
Pharos P35626 (Tbio)
Reactome R-HSA-418555 (G alpha (s) signalling events.)
R-HSA-8856825 (Cargo recognition for clathrin-mediated endocytosis.)
UniProt P35626 Q9UGW9

Target Cross References - Domain

InterPro IPR000239 (GPCR_kinase.)
IPR000719 (Prot_kinase_dom.)
IPR000961 (AGC-kinase_C.)
IPR001849 (PH_domain.)
IPR008271 (Ser/Thr_kinase_AS.)
IPR011009 (Kinase-like_dom.)
IPR011993 (PH_dom-like.)
IPR016137 (RGS.)
IPR017441 (Protein_kinase_ATP_BS.)
Pfam PF00069 (Pkinase)
PF00169 (PH)
PF00615 (RGS)
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