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Target Report Card

Target Name and Classification

Target ID CHEMBL1075158
Preferred Name Testosterone 17-beta-dehydrogenase 3
Synonyms 17-beta-HSD 3 | 17-beta-hydroxysteroid dehydrogenase type 3 | Edh17b3 | Hsd17b3 | Testicular 17-beta-hydroxysteroid dehydrogenase | Testosterone 17-beta-dehydrogenase 3
Organism Rattus norvegicus
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Testosterone 17-beta-dehydrogenase 3 SINGLE PROTEIN O54939

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0005783 (endoplasmic reticulum)
GO:0043231 (intracellular membrane-bounded organelle)
GO Molecular Function GO:0004303 (estradiol 17-beta-dehydrogenase activity)
GO:0016491 (oxidoreductase activity)
GO:0047035 (testosterone dehydrogenase (NAD+) activity)
GO:0047045 (testosterone 17-beta-dehydrogenase (NADP+) activity)
GO Biological Process GO:0006082 (organic acid metabolic process)
GO:0006629 (lipid metabolic process)
GO:0006694 (steroid biosynthetic process)
GO:0009635 (response to herbicide)
GO:0010038 (response to metal ion)
GO:0010288 (response to lead ion)
GO:0014070 (response to organic cyclic compound)
GO:0014823 (response to activity)
GO:0017085 (response to insecticide)
GO:0017143 (insecticide metabolic process)
GO:0018879 (biphenyl metabolic process)
GO:0018958 (phenol-containing compound metabolic process)
GO:0021766 (hippocampus development)
GO:0030539 (male genitalia development)
GO:0031667 (response to nutrient levels)
GO:0032870 (cellular response to hormone stimulus)
GO:0033197 (response to vitamin E)
GO:0033327 (Leydig cell differentiation)
GO:0033591 (response to L-ascorbic acid)
GO:0043627 (response to estrogen)
GO:0045471 (response to ethanol)
GO:0046685 (response to arsenic-containing substance)
GO:0046686 (response to cadmium ion)
GO:0048545 (response to steroid hormone)
GO:0051412 (response to corticosterone)
GO:0055114 (oxidation-reduction process)
GO:0060992 (response to fungicide)
GO:0061370 (testosterone biosynthetic process)
GO:0070542 (response to fatty acid)
GO:0071236 (cellular response to antibiotic)
GO:0071371 (cellular response to gonadotropin stimulus)

Target Cross References - Protein

canSAR O54939
UniProt O54939

Target Cross References - Domain

InterPro IPR002347 (SDR_fam.)
IPR033281 (HSD17B3.)
IPR036291 (NAD(P)-bd_dom_sf.)
Pfam PF00106 (adh_short)