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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL1075133
Target Type SINGLE PROTEIN
Preferred Name G protein-coupled receptor kinase 7
Synonyms G protein-coupled receptor kinase 7 | G protein-coupled receptor kinase GRK7 | GPRK7 | GRK7 | Rhodopsin kinase
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > agc protein kinase group > agc protein kinase grk family > agc protein kinase grk subfamily

Target Components

Component Description Relationship Accession
Rhodopsin kinase SINGLE PROTEIN Q8WTQ7

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000114124
Ensembl ENSG00000114124
GO Cellular Component GO:0016020 (membrane)
GO:0097381 (photoreceptor disc membrane)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0004672 (protein kinase activity)
GO:0004674 (protein serine/threonine kinase activity)
GO:0004703 (G-protein coupled receptor kinase activity)
GO:0005524 (ATP binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO:0050254 (rhodopsin kinase activity)
GO Biological Process GO:0006468 (protein phosphorylation)
GO:0007165 (signal transduction)
GO:0007601 (visual perception)
GO:0016310 (phosphorylation)
GO:0022400 (regulation of rhodopsin mediated signaling pathway)
GO:0046777 (protein autophosphorylation)
GO:0050896 (response to stimulus)

Target Cross References - Protein

canSAR Q8WTQ7
Human Protein Atlas ENSG00000114124
IntAct Q8WTQ7
Guide to Pharmacology 1471
Open Targets ENSG00000114124
PharmGKB PA38433
Pharos Q8WTQ7 (Tchem)
Reactome R-HSA-2514859 (Inactivation, recovery and regulation of the phototransduction cascade.)
UniProt Q8WTQ7

Target Cross References - Domain

InterPro IPR000239 (GPCR_kinase.)
IPR000719 (Prot_kinase_dom.)
IPR000961 (AGC-kinase_C.)
IPR008271 (Ser/Thr_kinase_AS.)
IPR011009 (Kinase-like_dom_sf.)
IPR016137 (RGS.)
IPR017441 (Protein_kinase_ATP_BS.)
IPR036305 (RGS_sf.)
Pfam PF00069 (Pkinase)
PF00615 (RGS)
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