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Target Report Card

Target Name and Classification

Target ID CHEMBL1075104
Preferred Name Leucine-rich repeat serine/threonine-protein kinase 2
Synonyms Dardarin | LRRK2 | Leucine-rich repeat serine/threonine-protein kinase 2 | PARK8
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > tkl protein kinase group > tkl protein kinase lrrk family

Target Components

Component Description Relationship Accession
Leucine-rich repeat serine/threonine-protein kinase 2 SINGLE PROTEIN Q5S007

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000188906
Ensembl ENSG00000188906
GO Cellular Component GO:0005615 (extracellular space)
GO:0005622 (intracellular)
GO:0005634 (nucleus)
GO:0005737 (cytoplasm)
GO:0005739 (mitochondrion)
GO:0005741 (mitochondrial outer membrane)
GO:0005743 (mitochondrial inner membrane)
GO:0005759 (mitochondrial matrix)
GO:0005764 (lysosome)
GO:0005768 (endosome)
GO:0005783 (endoplasmic reticulum)
GO:0005794 (Golgi apparatus)
GO:0005798 (Golgi-associated vesicle)
GO:0005802 (trans-Golgi network)
GO:0005829 (cytosol)
GO:0005886 (plasma membrane)
GO:0005902 (microvillus)
GO:0008021 (synaptic vesicle)
GO:0016020 (membrane)
GO:0016234 (inclusion body)
GO:0030054 (cell junction)
GO:0030424 (axon)
GO:0030425 (dendrite)
GO:0030426 (growth cone)
GO:0030672 (synaptic vesicle membrane)
GO:0031410 (cytoplasmic vesicle)
GO:0031966 (mitochondrial membrane)
GO:0032473 (cytoplasmic side of mitochondrial outer membrane)
GO:0032839 (dendrite cytoplasm)
GO:0042995 (cell projection)
GO:0043005 (neuron projection)
GO:0043025 (neuronal cell body)
GO:0043195 (terminal bouton)
GO:0043204 (perikaryon)
GO:0043231 (intracellular membrane-bounded organelle)
GO:0044753 (amphisome)
GO:0044754 (autolysosome)
GO:0045121 (membrane raft)
GO:0045202 (synapse)
GO:0070062 (extracellular exosome)
GO:0097487 (multivesicular body, internal vesicle)
GO:0098794 (postsynapse)
GO:0099400 (caveola neck)
GO:1990909 (Wnt signalosome)
GO Molecular Function GO:0000149 (SNARE binding)
GO:0000166 (nucleotide binding)
GO:0003779 (actin binding)
GO:0003924 (GTPase activity)
GO:0004672 (protein kinase activity)
GO:0004674 (protein serine/threonine kinase activity)
GO:0004708 (MAP kinase kinase activity)
GO:0005096 (GTPase activator activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0005525 (GTP binding)
GO:0008017 (microtubule binding)
GO:0015631 (tubulin binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO:0017048 (Rho GTPase binding)
GO:0017075 (syntaxin-1 binding)
GO:0030159 (receptor signaling complex scaffold activity)
GO:0030276 (clathrin binding)
GO:0034211 (GTP-dependent protein kinase activity)
GO:0036479 (peroxidase inhibitor activity)
GO:0039706 (co-receptor binding)
GO:0042802 (identical protein binding)
GO:0042803 (protein homodimerization activity)
GO:0044325 (ion channel binding)
GO:0051018 (protein kinase A binding)
GO:1904713 (beta-catenin destruction complex binding)
GO Biological Process GO:0000165 (MAPK cascade)
GO:0000186 (activation of MAPKK activity)
GO:0000187 (activation of MAPK activity)
GO:0001933 (negative regulation of protein phosphorylation)
GO:0001934 (positive regulation of protein phosphorylation)
GO:0006468 (protein phosphorylation)
GO:0006897 (endocytosis)
GO:0006914 (autophagy)
GO:0006979 (response to oxidative stress)
GO:0007005 (mitochondrion organization)
GO:0007030 (Golgi organization)
GO:0007040 (lysosome organization)
GO:0007283 (spermatogenesis)
GO:0007528 (neuromuscular junction development)
GO:0008340 (determination of adult lifespan)
GO:0009267 (cellular response to starvation)
GO:0010468 (regulation of gene expression)
GO:0010506 (regulation of autophagy)
GO:0010508 (positive regulation of autophagy)
GO:0010738 (regulation of protein kinase A signaling)
GO:0010955 (negative regulation of protein processing)
GO:0010977 (negative regulation of neuron projection development)
GO:0014041 (regulation of neuron maturation)
GO:0016242 (negative regulation of macroautophagy)
GO:0016310 (phosphorylation)
GO:0018105 (peptidyl-serine phosphorylation)
GO:0018107 (peptidyl-threonine phosphorylation)
GO:0019722 (calcium-mediated signaling)
GO:0021756 (striatum development)
GO:0021772 (olfactory bulb development)
GO:0022028 (tangential migration from the subventricular zone to the olfactory bulb)
GO:0030154 (cell differentiation)
GO:0031398 (positive regulation of protein ubiquitination)
GO:0032091 (negative regulation of protein binding)
GO:0032092 (positive regulation of protein binding)
GO:0032436 (positive regulation of proteasomal ubiquitin-dependent protein catabolic process)
GO:0033160 (positive regulation of protein import into nucleus, translocation)
GO:0034260 (negative regulation of GTPase activity)
GO:0034599 (cellular response to oxidative stress)
GO:0034613 (cellular protein localization)
GO:0035556 (intracellular signal transduction)
GO:0035564 (regulation of kidney size)
GO:0035640 (exploration behavior)
GO:0035641 (locomotory exploration behavior)
GO:0035751 (regulation of lysosomal lumen pH)
GO:0040012 (regulation of locomotion)
GO:0042391 (regulation of membrane potential)
GO:0043068 (positive regulation of programmed cell death)
GO:0043406 (positive regulation of MAP kinase activity)
GO:0043547 (positive regulation of GTPase activity)
GO:0046039 (GTP metabolic process)
GO:0046777 (protein autophosphorylation)
GO:0048312 (intracellular distribution of mitochondria)
GO:0048812 (neuron projection morphogenesis)
GO:0051646 (mitochondrion localization)
GO:0051770 (positive regulation of nitric-oxide synthase biosynthetic process)
GO:0051900 (regulation of mitochondrial depolarization)
GO:0051966 (regulation of synaptic transmission, glutamatergic)
GO:0060070 (canonical Wnt signaling pathway)
GO:0060079 (excitatory postsynaptic potential)
GO:0060159 (regulation of dopamine receptor signaling pathway)
GO:0060161 (positive regulation of dopamine receptor signaling pathway)
GO:0060828 (regulation of canonical Wnt signaling pathway)
GO:0061001 (regulation of dendritic spine morphogenesis)
GO:0070585 (protein localization to mitochondrion)
GO:0070997 (neuron death)
GO:0071287 (cellular response to manganese ion)
GO:0071407 (cellular response to organic cyclic compound)
GO:0072593 (reactive oxygen species metabolic process)
GO:0090140 (regulation of mitochondrial fission)
GO:0090263 (positive regulation of canonical Wnt signaling pathway)
GO:0090394 (negative regulation of excitatory postsynaptic potential)
GO:0140058 (neuron projection arborization)
GO:1900244 (positive regulation of synaptic vesicle endocytosis)
GO:1901214 (regulation of neuron death)
GO:1901215 (negative regulation of neuron death)
GO:1901727 (positive regulation of histone deacetylase activity)
GO:1902236 (negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)
GO:1902499 (positive regulation of protein autoubiquitination)
GO:1902692 (regulation of neuroblast proliferation)
GO:1902803 (regulation of synaptic vesicle transport)
GO:1902823 (negative regulation of late endosome to lysosome transport)
GO:1902902 (negative regulation of autophagosome assembly)
GO:1903125 (negative regulation of thioredoxin peroxidase activity by peptidyl-threonine phosphorylation)
GO:1903206 (negative regulation of hydrogen peroxide-induced cell death)
GO:1903215 (negative regulation of protein targeting to mitochondrion)
GO:1903217 (negative regulation of protein processing involved in protein targeting to mitochondrion)
GO:1903351 (cellular response to dopamine)
GO:1903980 (positive regulation of microglial cell activation)
GO:1904469 (positive regulation of tumor necrosis factor secretion)
GO:1904887 (Wnt signalosome assembly)
GO:1905279 (regulation of retrograde transport, endosome to Golgi)
GO:1905289 (regulation of CAMKK-AMPK signaling cascade)
GO:2000172 (regulation of branching morphogenesis of a nerve)
GO:2000300 (regulation of synaptic vesicle exocytosis)
Wikipedia LRRK2

Target Cross References - Protein

canSAR Q5S007
CGD Parkinson disease 8; Dementia, Lewy body
Human Protein Atlas ENSG00000188906
IntAct Q5S007
Guide to Pharmacology 2059
Open Targets ENSG00000188906
PharmGKB PA134968052
Pharos Q5S007 (Tchem)
Reactome R-HSA-8857538 (PTK6 promotes HIF1A stabilization.)
UniProt A6NJU2 Q5S007 Q6ZS50 Q8NCX9

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_dom.)
IPR001611 (Leu-rich_rpt.)
IPR003591 (Leu-rich_rpt_typical-subtyp.)
IPR005225 (Small_GTP-bd_dom.)
IPR008271 (Ser/Thr_kinase_AS.)
IPR011009 (Kinase-like_dom_sf.)
IPR011989 (ARM-like.)
IPR015943 (WD40/YVTN_repeat-like_dom_sf.)
IPR016024 (ARM-type_fold.)
IPR017441 (Protein_kinase_ATP_BS.)
IPR020859 (ROC_dom.)
IPR025875 (Leu-rich_rpt_4.)
IPR027417 (P-loop_NTPase.)
IPR032171 (COR.)
IPR032675 (LRR_dom_sf.)
IPR036322 (WD40_repeat_dom_sf.)
IPR036770 (Ankyrin_rpt-contain_sf.)
Pfam PF00069 (Pkinase)
PF12799 (LRR_4)
PF13855 (LRR_8)
PF16095 (COR)

Target Cross References - Structure