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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL1075104
Target Type SINGLE PROTEIN
Preferred Name Leucine-rich repeat serine/threonine-protein kinase 2
Synonyms Dardarin | LRRK2 | Leucine-rich repeat serine/threonine-protein kinase 2 | PARK8
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > tkl protein kinase group > tkl protein kinase lrrk family

Target Components

Component Description Relationship Accession
Leucine-rich repeat serine/threonine-protein kinase 2 SINGLE PROTEIN Q5S007

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000188906
Ensembl ENSG00000188906
GO Cellular Component GO:0032473 (external side of mitochondrial outer membrane)
GO Molecular Function GO:0004708 (MAP kinase kinase activity)
GO:0005096 (GTPase activator activity)
GO:0005524 (ATP binding)
GO:0005525 (GTP binding)
GO:0015631 (tubulin binding)
GO:0034211 (GTP-dependent protein kinase activity)
GO:0042803 (protein homodimerization activity)
GO Biological Process GO:0000186 (activation of MAPKK activity)
GO:0001934 (positive regulation of protein phosphorylation)
GO:0006979 (response to oxidative stress)
GO:0007264 (small GTPase mediated signal transduction)
GO:0007406 (negative regulation of neuroblast proliferation)
GO:0007528 (neuromuscular junction development)
GO:0008340 (determination of adult lifespan)
GO:0010508 (positive regulation of autophagy)
GO:0014043 (negative regulation of neuron maturation)
GO:0018105 (peptidyl-serine phosphorylation)
GO:0022028 (tangential migration from the subventricular zone to the olfactory bulb)
GO:0031398 (positive regulation of protein ubiquitination)
GO:0032436 (positive regulation of proteasomal ubiquitin-dependent protein catabolic process)
GO:0035564 (regulation of kidney size)
GO:0035640 (exploration behavior)
GO:0040012 (regulation of locomotion)
GO:0042391 (regulation of membrane potential)
GO:0043068 (positive regulation of programmed cell death)
GO:0046777 (protein autophosphorylation)
GO:0048312 (intracellular distribution of mitochondria)
GO:0060161 (positive regulation of dopamine receptor signaling pathway)
GO:0061002 (negative regulation of dendritic spine morphogenesis)
GO:0070997 (neuron death)
GO:2000173 (negative regulation of branching morphogenesis of a nerve)
Wikipedia LRRK2

Target Cross References - Protein

canSAR Q5S007
CGD Parkinson disease 8; Dementia, Lewy body
Human Protein Atlas ENSG00000188906
Guide to Pharmacology 2059 (leucine-rich repeat kinase 2)
PharmGKB PA134968052
UniProt A6NJU2 Q5S007 Q6ZS50 Q8NCX9

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_cat_dom.)
IPR001611 (Leu-rich_rpt.)
IPR001680 (WD40_repeat.)
IPR001806 (Ras_GTPase.)
IPR003591 (Leu-rich_rpt_typical-subtyp.)
IPR005225 (Small_GTP-bd_dom.)
IPR008271 (Ser/Thr_prot_kinase_AS.)
IPR011009 (Kinase-like_dom.)
IPR011046 (WD40_repeat-like_dom.)
IPR011989 (ARM-like.)
IPR013684 (MIRO-like.)
IPR015943 (WD40/YVTN_repeat-like_dom.)
IPR016024 (ARM-type_fold.)
IPR017441 (Protein_kinase_ATP_BS.)
IPR017442 (Se/Thr_prot_kinase-like_dom.)
IPR020683 (Ankyrin_rpt-contain_dom.)
IPR020859 (ROC_GTPase.)
Pfam PF00069 (Pkinase)
PF00560 (LRR_1)
PF08477 (Miro)

Target Cross References - Structure

PDBe 2ZEJ 3D6T
CREDO 2ZEJ 3D6T
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