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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL1075097
Target Type SINGLE PROTEIN
Preferred Name Arginase-1
Synonyms ARG1 | Arginase-1 | Liver-type arginase | Type I arginase
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Arginase-1 SINGLE PROTEIN P05089

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000118520
Ensembl ENSG00000118520
GO Cellular Component GO:0005615 (extracellular space)
GO:0005634 (nucleus)
GO:0005737 (cytoplasm)
GO:0005741 (mitochondrial outer membrane)
GO:0005829 (cytosol)
GO:0043005 (neuron projection)
GO:0043025 (neuronal cell body)
GO:0070062 (extracellular exosome)
GO Molecular Function GO:0004053 (arginase activity)
GO:0016787 (hydrolase activity)
GO:0016813 (hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines)
GO:0030145 (manganese ion binding)
GO:0046872 (metal ion binding)
GO Biological Process GO:0000050 (urea cycle)
GO:0001889 (liver development)
GO:0001938 (positive regulation of endothelial cell proliferation)
GO:0006525 (arginine metabolic process)
GO:0006527 (arginine catabolic process)
GO:0007565 (female pregnancy)
GO:0007568 (aging)
GO:0009611 (response to wounding)
GO:0009635 (response to herbicide)
GO:0010042 (response to manganese ion)
GO:0010043 (response to zinc ion)
GO:0010269 (response to selenium ion)
GO:0010963 (regulation of L-arginine import)
GO:0014075 (response to amine)
GO:0019547 (arginine catabolic process to ornithine)
GO:0030324 (lung development)
GO:0032496 (response to lipopolysaccharide)
GO:0032964 (collagen biosynthetic process)
GO:0033189 (response to vitamin A)
GO:0033197 (response to vitamin E)
GO:0042493 (response to drug)
GO:0043200 (response to amino acid)
GO:0043434 (response to peptide hormone)
GO:0046686 (response to cadmium ion)
GO:0048545 (response to steroid hormone)
GO:0048678 (response to axon injury)
GO:0051597 (response to methylmercury)
GO:0060056 (mammary gland involution)
GO:0060135 (maternal process involved in female pregnancy)
GO:0070207 (protein homotrimerization)
GO:0070301 (cellular response to hydrogen peroxide)
GO:0071222 (cellular response to lipopolysaccharide)
GO:0071353 (cellular response to interleukin-4)
GO:0071377 (cellular response to glucagon stimulus)
GO:0071549 (cellular response to dexamethasone stimulus)
GO:0071560 (cellular response to transforming growth factor beta stimulus)

Target Cross References - Protein

canSAR P05089
CGD Hyperargininemia
Human Protein Atlas ENSG00000118520
IntAct P05089
Guide to Pharmacology 1244
Open Targets ENSG00000118520
PharmGKB PA24947
Reactome R-HSA-6798695 (Neutrophil degranulation.)
R-HSA-70635 (Urea cycle.)
UniProt A6NEA0 P05089 Q5JWT5 Q5JWT6 Q8TE72 Q9BS50

Target Cross References - Domain

InterPro IPR006035 (Ureohydrolase.)
IPR014033 (Arginase.)
IPR020855 (Ureohydrolase_Mn_BS.)
IPR023696 (Ureohydrolase_domain.)
Pfam PF00491 (Arginase)

Target Cross References - Structure

PDBe 1WVA 1WVB 2AEB 2PHA 2PHO 2PLL 2ZAV 3DJ8 3E6K 3E6V 3F80 3GMZ 3GN0 3KV2 3LP4 3LP7 3MFV 3MFW 3MJL 3SJT 3SKK 3TF3 3TH7 3THE More...
CREDO 1WVA 1WVB 2AEB 2PHA 2PHO 2PLL 2ZAV 3DJ8 3E6K 3E6V 3F80 3GMZ 3GN0 3KV2 3LP4 3LP7 3MFV 3MFW 3MJL 3SJT 3SKK 3TF3 3TH7 3THE More...
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