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Target Report Card

Target Name and Classification

Target ID CHEMBL6190
Preferred Name Voltage-dependent anion-selective channel protein 2
Synonyms Outer mitochondrial membrane protein porin 2 | VDAC-2 | VDAC2 | Voltage-dependent anion-selective channel protein 2 | hVDAC2
Organism Homo sapiens
Species Group No
Protein Target Classification
  • ion channel > other ion channel > mitochondrial and plastid porin family > voltage-dependent anion-selective channel

Target Components

Component Description Relationship Accession
Voltage-dependent anion-selective channel protein 2 SINGLE PROTEIN P45880

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000165637
Ensembl ENSG00000165637
GO Cellular Component GO:0005634 (nucleus)
GO:0005739 (mitochondrion)
GO:0005741 (mitochondrial outer membrane)
GO:0005743 (mitochondrial inner membrane)
GO:0008021 (synaptic vesicle)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0042645 (mitochondrial nucleoid)
GO:0043209 (myelin sheath)
GO:0045121 (membrane raft)
GO:0046930 (pore complex)
GO:0070062 (extracellular exosome)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0005515 (protein binding)
GO:0008308 (voltage-gated anion channel activity)
GO:0015288 (porin activity)
GO Biological Process GO:0006810 (transport)
GO:0006811 (ion transport)
GO:0006820 (anion transport)
GO:0032272 (negative regulation of protein polymerization)
GO:0044070 (regulation of anion transport)
GO:0055085 (transmembrane transport)
GO:1903959 (regulation of anion transmembrane transport)
GO:2001243 (negative regulation of intrinsic apoptotic signaling pathway)
Wikipedia VDAC2

Target Cross References - Protein

canSAR P45880
Human Protein Atlas ENSG00000165637
IntAct P45880
Open Targets ENSG00000165637
PharmGKB PA37295
Reactome R-HSA-5689880 (Ub-specific processing proteases.)
UniProt P45880 Q5VWK1 Q5VWK3 Q6IB40 Q7L3J5 Q9BWK8 Q9Y5I6

Target Cross References - Domain

InterPro IPR001925 (Porin_Euk.)
IPR023614 (Porin_dom.)
IPR027246 (Porin_Euk/Tom40.)
Pfam PF01459 (Porin_3)