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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL6177
Target Type SINGLE PROTEIN
Preferred Name NAD kinase
Synonyms NAD kinase | NADK | Poly(P)/ATP NAD kinase
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
NAD kinase SINGLE PROTEIN O95544

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000008130
Ensembl ENSG00000008130
GO Cellular Component GO:0005829 (cytosol)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0003951 (NAD+ kinase activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO:0046872 (metal ion binding)
GO Biological Process GO:0006741 (NADP biosynthetic process)
GO:0008152 (metabolic process)
GO:0016310 (phosphorylation)
GO:0019674 (NAD metabolic process)
GO:0046034 (ATP metabolic process)
Wikipedia NAD%2B_kinase

Target Cross References - Protein

canSAR O95544
Human Protein Atlas ENSG00000008130
IntAct O95544
Open Targets ENSG00000008130
PharmGKB PA142671298
Reactome R-HSA-196807 (Nicotinate metabolism.)
UniProt A6NNN3 A8K296 B7Z434 F5GXR5 O95544 Q5QPS4 Q9H2P2 Q9H931

Target Cross References - Domain

InterPro IPR002504 (NADK.)
IPR016064 (NAD/diacylglycerol_kinase.)
IPR017437 (ATP-NAD_kinase_PpnK-typ_all-b.)
IPR017438 (ATP-NAD_kinase_dom_1.)
Pfam PF01513 (NAD_kinase)

Target Cross References - Structure

PDBe 3PFN
CREDO 3PFN
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