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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL6174
Target Type SINGLE PROTEIN
Preferred Name Cytochrome c oxidase subunit 2
Synonyms COII | COXII | Cytochrome c oxidase polypeptide II | Cytochrome c oxidase subunit 2 | MT-CO2 | MTCO2
Organism Homo sapiens
Species Group No
Protein Target Classification
  • transporter > primary active transporter > oxidoreduction-driven transporters

Target Components

Component Description Relationship Accession
Cytochrome c oxidase subunit 2 SINGLE PROTEIN P00403

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000198712
Ensembl ENSG00000198712
GO Cellular Component GO:0005739 (mitochondrion)
GO:0005743 (mitochondrial inner membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0045277 (respiratory chain complex IV)
GO:0070062 (extracellular exosome)
GO:0070469 (respiratory chain)
GO Molecular Function GO:0004129 (cytochrome-c oxidase activity)
GO:0005507 (copper ion binding)
GO:0005515 (protein binding)
GO:0016491 (oxidoreductase activity)
GO:0046872 (metal ion binding)
GO Biological Process GO:0006123 (mitochondrial electron transport, cytochrome c to oxygen)
GO:0007595 (lactation)
GO:0009409 (response to cold)
GO:0022900 (electron transport chain)
GO:0055114 (oxidation-reduction process)
GO:1902600 (hydrogen ion transmembrane transport)
Wikipedia MT-CO2

Target Cross References - Protein

canSAR P00403
Human Protein Atlas ENSG00000198712
IntAct P00403
Open Targets ENSG00000198712
PharmGKB PA31227
Reactome R-HSA-5628897 (TP53 Regulates Metabolic Genes.)
R-HSA-611105 (Respiratory electron transport.)
UniProt P00403 Q37526

Target Cross References - Domain

InterPro IPR001505 (Copper_CuA.)
IPR002429 (Cyt_c_oxidase_su2_C.)
IPR008972 (Cupredoxin.)
IPR011759 (Cyt_c_oxidase_su2_TM_dom.)
IPR014222 (Cyt_c_oxidase_su2.)
Pfam PF00116 (COX2)
PF02790 (COX2_TM)

Target Cross References - Structure

PDBe 3VRJ
CREDO 3VRJ
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