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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL6173
Target Type SINGLE PROTEIN
Preferred Name Cytochrome c oxidase subunit 1
Synonyms COI | COXI | Cytochrome c oxidase polypeptide I | Cytochrome c oxidase subunit 1 | MT-CO1 | MTCO1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • transporter > primary active transporter > oxidoreduction-driven transporters

Target Components

Component Description Relationship Accession
Cytochrome c oxidase subunit 1 SINGLE PROTEIN P00395

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000198804
Ensembl ENSG00000198804
GO Cellular Component GO:0005739 (mitochondrion)
GO:0005743 (mitochondrial inner membrane)
GO:0005751 (mitochondrial respiratory chain complex IV)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0045277 (respiratory chain complex IV)
GO:0070469 (respiratory chain)
GO Molecular Function GO:0004129 (cytochrome-c oxidase activity)
GO:0005506 (iron ion binding)
GO:0005515 (protein binding)
GO:0009055 (electron carrier activity)
GO:0016491 (oxidoreductase activity)
GO:0020037 (heme binding)
GO:0046872 (metal ion binding)
GO Biological Process GO:0006119 (oxidative phosphorylation)
GO:0006123 (mitochondrial electron transport, cytochrome c to oxygen)
GO:0006979 (response to oxidative stress)
GO:0007568 (aging)
GO:0009060 (aerobic respiration)
GO:0021549 (cerebellum development)
GO:0046688 (response to copper ion)
GO:0051602 (response to electrical stimulus)
GO:0055114 (oxidation-reduction process)
GO:1902600 (hydrogen ion transmembrane transport)
Wikipedia MT-CO1

Target Cross References - Protein

canSAR P00395
CGD Deafness, mitochondrial
Human Protein Atlas ENSG00000198804
IntAct P00395
Open Targets ENSG00000198804
PharmGKB PA31225
Reactome R-HSA-5628897 (TP53 Regulates Metabolic Genes.)
R-HSA-611105 (Respiratory electron transport.)
UniProt P00395 Q34770

Target Cross References - Domain

InterPro IPR000883 (COX1.)
IPR023615 (Cyt_c_Oxase_su1_BS.)
IPR023616 (Cyt_c_Oxase_su1_dom.)
Pfam PF00115 (COX1)
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