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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL6173
Target Type SINGLE PROTEIN
Preferred Name Cytochrome c oxidase subunit 1
Synonyms COI | COXI | Cytochrome c oxidase polypeptide I | Cytochrome c oxidase subunit 1 | MT-CO1 | MTCO1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • transporter > primary active transporter > oxidoreduction-driven transporters

Target Components

Component Description Relationship Accession
Cytochrome c oxidase subunit 1 SINGLE PROTEIN P00395

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000198804
Ensembl ENSG00000198804
GO Cellular Component GO:0005743 (mitochondrial inner membrane)
GO:0016021 (integral to membrane)
GO:0070469 (respiratory chain)
GO Molecular Function GO:0004129 (cytochrome-c oxidase activity)
GO:0005515 (protein binding)
GO:0009055 (electron carrier activity)
GO:0020037 (heme binding)
GO Biological Process GO:0006123 (mitochondrial electron transport, cytochrome c to oxygen)
GO:0009060 (aerobic respiration)
Wikipedia MT-CO1

Target Cross References - Protein

canSAR P00395
CGD Deafness, mitochondrial
Human Protein Atlas ENSG00000198804
IntAct P00395
PharmGKB PA31225
Reactome REACT_6305 (Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.)
UniProt P00395 Q34770

Target Cross References - Domain

InterPro IPR000883 (Cyt_c_Oxase_su1.)
IPR023615 (Cyt_c_Oxase_su1_BS.)
IPR023616 (Cyt_c_Oxase_su1_dom.)
Pfam PF00115 (COX1)
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