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Target Report Card

Target Name and Classification

Target ID CHEMBL6167
Target Type SINGLE PROTEIN
Preferred Name Serine/threonine-protein kinase LATS1
Synonyms LATS1 | Large tumor suppressor homolog 1 | Serine/threonine-protein kinase LATS1 | WARTS protein kinase | WARTS | h-warts
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > agc protein kinase group > agc protein kinase ndr family

Target Components

Component Description Relationship Accession
Serine/threonine-protein kinase LATS1 SINGLE PROTEIN O95835

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000131023
Ensembl ENSG00000131023
GO Cellular Component GO:0000922 (spindle pole)
GO:0005737 (cytoplasm)
GO:0005815 (microtubule organizing center)
GO:0005829 (cytosol)
GO:0005856 (cytoskeleton)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0000287 (magnesium ion binding)
GO:0004672 (protein kinase activity)
GO:0004674 (protein serine/threonine kinase activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO:0019901 (protein kinase binding)
GO:0046872 (metal ion binding)
GO Biological Process GO:0000082 (G1/S transition of mitotic cell cycle)
GO:0000086 (G2/M transition of mitotic cell cycle)
GO:0000819 (sister chromatid segregation)
GO:0001827 (inner cell mass cell fate commitment)
GO:0001828 (inner cell mass cellular morphogenesis)
GO:0006468 (protein phosphorylation)
GO:0007049 (cell cycle)
GO:0007067 (mitotic nuclear division)
GO:0009755 (hormone-mediated signaling pathway)
GO:0016310 (phosphorylation)
GO:0030216 (keratinocyte differentiation)
GO:0030833 (regulation of actin filament polymerization)
GO:0033138 (positive regulation of peptidyl-serine phosphorylation)
GO:0034613 (cellular protein localization)
GO:0035329 (hippo signaling)
GO:0043065 (positive regulation of apoptotic process)
GO:0043254 (regulation of protein complex assembly)
GO:0045736 (negative regulation of cyclin-dependent protein serine/threonine kinase activity)
GO:0046620 (regulation of organ growth)
GO:0051220 (cytoplasmic sequestering of protein)
GO:0051301 (cell division)
GO:0090090 (negative regulation of canonical Wnt signaling pathway)
Wikipedia LATS1

Target Cross References - Protein

canSAR O95835
Human Protein Atlas ENSG00000131023
IntAct O95835
Guide to Pharmacology 1515
Open Targets ENSG00000131023
PharmGKB PA30301
Pharos O95835 (Tbio)
Reactome R-HSA-2028269 (Signaling by Hippo.)
UniProt O95835 Q6PKD0

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_dom.)
IPR000961 (AGC-kinase_C.)
IPR008271 (Ser/Thr_kinase_AS.)
IPR009060 (UBA-like.)
IPR011009 (Kinase-like_dom.)
IPR015940 (UBA.)
IPR028741 (LATS1/Warts.)
Pfam PF00069 (Pkinase)
PF00627 (UBA)

Target Cross References - Structure

PDBe 4ZRK 5B5W 5BRK
CREDO 4ZRK 5B5W 5BRK
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