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Target Report Card

Target Name and Classification

Target ID CHEMBL6164
Preferred Name Tankyrase-1
Synonyms ADP-ribosyltransferase diphtheria toxin-like 5 | ARTD5 | PARP5A | PARPL | Poly [ADP-ribose] polymerase 5A | TANK1 | TIN1 | TINF1 | TNKS | TNKS-1 | TNKS1 | TRF1-interacting ankyrin-related ADP-ribose polymerase | Tankyrase I | Tankyrase-1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Tankyrase-1 SINGLE PROTEIN O95271

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL3038515 Tankyrase 1/2 PROTEIN FAMILY

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000173273
Ensembl ENSG00000173273
GO Cellular Component GO:0000139 (Golgi membrane)
GO:0000242 (pericentriolar material)
GO:0000775 (chromosome, centromeric region)
GO:0000781 (chromosome, telomeric region)
GO:0000784 (nuclear chromosome, telomeric region)
GO:0000922 (spindle pole)
GO:0005634 (nucleus)
GO:0005643 (nuclear pore)
GO:0005694 (chromosome)
GO:0005737 (cytoplasm)
GO:0005794 (Golgi apparatus)
GO:0005829 (cytosol)
GO:0005856 (cytoskeleton)
GO:0016020 (membrane)
GO:0031965 (nuclear membrane)
GO Molecular Function GO:0003950 (NAD+ ADP-ribosyltransferase activity)
GO:0005515 (protein binding)
GO:0008270 (zinc ion binding)
GO:0016740 (transferase activity)
GO:0016757 (transferase activity, transferring glycosyl groups)
GO:0042393 (histone binding)
GO:0046872 (metal ion binding)
GO Biological Process GO:0000209 (protein polyubiquitination)
GO:0006471 (protein ADP-ribosylation)
GO:0006810 (transport)
GO:0007049 (cell cycle)
GO:0007052 (mitotic spindle organization)
GO:0007067 (mitotic nuclear division)
GO:0015031 (protein transport)
GO:0016055 (Wnt signaling pathway)
GO:0018105 (peptidyl-serine phosphorylation)
GO:0018107 (peptidyl-threonine phosphorylation)
GO:0032210 (regulation of telomere maintenance via telomerase)
GO:0032212 (positive regulation of telomere maintenance via telomerase)
GO:0045944 (positive regulation of transcription from RNA polymerase II promoter)
GO:0051028 (mRNA transport)
GO:0051225 (spindle assembly)
GO:0051301 (cell division)
GO:0051973 (positive regulation of telomerase activity)
GO:0070198 (protein localization to chromosome, telomeric region)
GO:0070212 (protein poly-ADP-ribosylation)
GO:0070213 (protein auto-ADP-ribosylation)
GO:0090263 (positive regulation of canonical Wnt signaling pathway)
GO:1904355 (positive regulation of telomere capping)
GO:1904357 (negative regulation of telomere maintenance via telomere lengthening)
GO:1904743 (negative regulation of telomeric DNA binding)
GO:1904908 (negative regulation of maintenance of mitotic sister chromatid cohesion, telomeric)
Wikipedia TNKS

Target Cross References - Protein

canSAR O95271
Human Protein Atlas ENSG00000173273
IntAct O95271
Open Targets ENSG00000173273
PharmGKB PA36631
Reactome R-HSA-201681 (TCF dependent signaling in response to WNT.)
R-HSA-4641257 (Degradation of AXIN.)
R-HSA-5545619 (XAV939 inhibits tankyrase, stabilizing AXIN.)
R-HSA-5689880 (Ub-specific processing proteases.)
UniProt O95271 O95272 Q4G0F2

Target Cross References - Domain

InterPro IPR001660 (SAM.)
IPR002110 (Ankyrin_rpt.)
IPR012317 (Poly(ADP-ribose)pol_cat_dom.)
IPR013761 (SAM/pointed.)
IPR020683 (Ankyrin_rpt-contain_dom.)
IPR028731 (TNKS.)
Pfam PF00023 (Ank)
PF00644 (PARP)
PF07647 (SAM_2)
PF12796 (Ank_2)
PF13606 (Ank_3)

Target Cross References - Structure

PDBe 2RF5 3UDD 3UH2 3UH4 4DVI 4I9I 4K4E 4K4F 4KRS 4LI6 4LI7 4LI8 4MSG 4MSK 4MT9 4N3R 4N4V 4OA7 4TOR 4TOS 4U6A 4UUH 4UW1 4W5S More...
CREDO 2RF5 3UDD 3UH2 3UH4 4DVI 4I9I 4K4E 4K4F 4KRS 4LI6 4LI7 4LI8 4MSG 4MSK 4MT9 4N3R 4N4V 4OA7 4TOR 4TOS 4U6A 4UUH 4UW1 4W5S More...