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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL6162
Preferred Name Serine/threonine-protein kinase PFTAIRE-1
Synonyms CDK14 | Cell division protein kinase 14 | Cyclin-dependent kinase 14 | KIAA0834 | PFTK1 | Serine/threonine-protein kinase PFTAIRE-1 | hPFTAIRE1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > cmgc protein kinase group > cmgc protein kinase cdk family > cmgc protein kinase pftaire

Target Components

Component Description Relationship Accession
Cyclin-dependent kinase 14 SINGLE PROTEIN O94921

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL3559691 Cyclin-dependent kinase PROTEIN FAMILY

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000058091
Ensembl ENSG00000058091
GO Cellular Component GO:0000308 (cytoplasmic cyclin-dependent protein kinase holoenzyme complex)
GO:0005634 (nucleus)
GO:0005737 (cytoplasm)
GO:0005829 (cytosol)
GO:0005886 (plasma membrane)
GO:0016020 (membrane)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0004672 (protein kinase activity)
GO:0004674 (protein serine/threonine kinase activity)
GO:0004693 (cyclin-dependent protein serine/threonine kinase activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO:0030332 (cyclin binding)
GO Biological Process GO:0000086 (G2/M transition of mitotic cell cycle)
GO:0006468 (protein phosphorylation)
GO:0007049 (cell cycle)
GO:0016055 (Wnt signaling pathway)
GO:0016310 (phosphorylation)
GO:0051301 (cell division)
GO:0051726 (regulation of cell cycle)
GO:0060828 (regulation of canonical Wnt signaling pathway)
Wikipedia PFTK1

Target Cross References - Protein

canSAR O94921
Human Protein Atlas ENSG00000058091
IntAct O94921
Guide to Pharmacology 1967
Open Targets ENSG00000058091
PharmGKB PA33221
Pharos O94921 (Tchem)
UniProt A4D1E6 A6NK51 A8WFP6 B4DHG5 B4DNM2 O94921 Q75N06 Q75N22 Q8N764 Q9H3D7 Q9UDR0

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_dom.)
IPR008271 (Ser/Thr_kinase_AS.)
IPR011009 (Kinase-like_dom.)
IPR017441 (Protein_kinase_ATP_BS.)
Pfam PF00069 (Pkinase)