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Target Report Card

Target Name and Classification

Target ID CHEMBL6159
Target Type SINGLE PROTEIN
Preferred Name Ubiquitin carboxyl-terminal hydrolase isozyme L1
Synonyms Neuron cytoplasmic protein 9.5 | PGP 9.5 | PGP9.5 | UCH-L1 | UCHL1 | Ubiquitin carboxyl-terminal hydrolase isozyme L1 | Ubiquitin thioesterase L1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Ubiquitin carboxyl-terminal hydrolase isozyme L1 SINGLE PROTEIN P09936

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000154277
Ensembl ENSG00000154277
GO Cellular Component GO:0005622 (intracellular)
GO:0005654 (nucleoplasm)
GO:0005737 (cytoplasm)
GO:0005783 (endoplasmic reticulum)
GO:0005789 (endoplasmic reticulum membrane)
GO:0005829 (cytosol)
GO:0005886 (plasma membrane)
GO:0016020 (membrane)
GO:0030424 (axon)
GO:0043025 (neuronal cell body)
GO:0043209 (myelin sheath)
GO:0044306 (neuron projection terminus)
GO:1904115 (axon cytoplasm)
GO Molecular Function GO:0004197 (cysteine-type endopeptidase activity)
GO:0004843 (thiol-dependent ubiquitin-specific protease activity)
GO:0005515 (protein binding)
GO:0008233 (peptidase activity)
GO:0008234 (cysteine-type peptidase activity)
GO:0008242 (omega peptidase activity)
GO:0016787 (hydrolase activity)
GO:0016874 (ligase activity)
GO:0031625 (ubiquitin protein ligase binding)
GO:0031694 (alpha-2A adrenergic receptor binding)
GO:0036459 (thiol-dependent ubiquitinyl hydrolase activity)
GO:0043130 (ubiquitin binding)
GO Biological Process GO:0002931 (response to ischemia)
GO:0006508 (proteolysis)
GO:0006511 (ubiquitin-dependent protein catabolic process)
GO:0007409 (axonogenesis)
GO:0007412 (axon target recognition)
GO:0007628 (adult walking behavior)
GO:0008283 (cell proliferation)
GO:0016241 (regulation of macroautophagy)
GO:0016579 (protein deubiquitination)
GO:0019233 (sensory perception of pain)
GO:0019896 (axonal transport of mitochondrion)
GO:0042755 (eating behavior)
GO:0043161 (proteasome-mediated ubiquitin-dependent protein catabolic process)
GO:0043407 (negative regulation of MAP kinase activity)
GO:0048747 (muscle fiber development)
GO:0050905 (neuromuscular process)
Wikipedia Ubiquitin_carboxy-terminal_hydrolase_L1

Target Cross References - Protein

canSAR P09936
CGD Parkinson disease 5, autosomal dominant; Early-onset progressive neurodegeneration, autosomal recessive
Human Protein Atlas ENSG00000154277
IntAct P09936
Guide to Pharmacology 2426
Open Targets ENSG00000154277
PharmGKB PA37160
Reactome R-HSA-5689603 (UCH proteinases.)
UniProt P09936 Q4W5K6 Q71UM0

Target Cross References - Domain

InterPro IPR001578 (Peptidase_C12_UCH.)
IPR030297 (UCHL1.)
IPR036959 (Peptidase_C12_UCH_sf.)
Pfam PF01088 (Peptidase_C12)

Target Cross References - Structure

PDBe 2ETL 3IFW 3IRT 3KVF 3KW5 4DM9 4JKJ
CREDO 2ETL 3IFW 3IRT 3KVF 3KW5 4DM9 4JKJ
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