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ChEMBL

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Target Report Card

Target Name and Classification

Target ID CHEMBL6157
Target Type SINGLE PROTEIN
Preferred Name Tumor susceptibility gene 101 protein
Synonyms ESCRT-I complex subunit TSG101 | TSG101 | Tumor susceptibility gene 101 protein
Organism Homo sapiens
Species Group No
Protein Target Classification
  • unclassified protein

Target Components

Component Description Relationship Accession
Tumor susceptibility gene 101 protein SINGLE PROTEIN Q99816

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000074319
Ensembl ENSG00000074319
GO Cellular Component GO:0000813 (ESCRT I complex)
GO:0005634 (nucleus)
GO:0005730 (nucleolus)
GO:0005737 (cytoplasm)
GO:0005768 (endosome)
GO:0005769 (early endosome)
GO:0005770 (late endosome)
GO:0005771 (multivesicular body)
GO:0005886 (plasma membrane)
GO:0010008 (endosome membrane)
GO:0016020 (membrane)
GO:0031902 (late endosome membrane)
GO:0070062 (extracellular exosome)
GO Molecular Function GO:0003677 (DNA binding)
GO:0003714 (transcription corepressor activity)
GO:0005515 (protein binding)
GO:0030374 (ligand-dependent nuclear receptor transcription coactivator activity)
GO:0031625 (ubiquitin protein ligase binding)
GO:0042803 (protein homodimerization activity)
GO:0043130 (ubiquitin binding)
GO:0046790 (virion binding)
GO:0048306 (calcium-dependent protein binding)
GO Biological Process GO:0001558 (regulation of cell growth)
GO:0006464 (cellular protein modification process)
GO:0006513 (protein monoubiquitination)
GO:0006810 (transport)
GO:0006914 (autophagy)
GO:0007049 (cell cycle)
GO:0007050 (cell cycle arrest)
GO:0008285 (negative regulation of cell proliferation)
GO:0008333 (endosome to lysosome transport)
GO:0015031 (protein transport)
GO:0016032 (viral process)
GO:0016197 (endosomal transport)
GO:0019058 (viral life cycle)
GO:0030154 (cell differentiation)
GO:0030216 (keratinocyte differentiation)
GO:0036258 (multivesicular body assembly)
GO:0039702 (viral budding via host ESCRT complex)
GO:0040008 (regulation of growth)
GO:0043162 (ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway)
GO:0043405 (regulation of MAP kinase activity)
GO:0045892 (negative regulation of transcription, DNA-templated)
GO:0046755 (viral budding)
GO:0048524 (positive regulation of viral process)
GO:0051301 (cell division)
GO:0075733 (intracellular transport of virus)
GO:0097352 (autophagosome maturation)
GO:1902186 (regulation of viral release from host cell)
GO:1902188 (positive regulation of viral release from host cell)
GO:1903543 (positive regulation of exosomal secretion)
GO:1903551 (regulation of extracellular exosome assembly)
GO:1903772 (regulation of viral budding via host ESCRT complex)
GO:1903774 (positive regulation of viral budding via host ESCRT complex)
GO:2000397 (positive regulation of ubiquitin-dependent endocytosis)
Wikipedia TSG101

Target Cross References - Protein

canSAR Q99816
Human Protein Atlas ENSG00000074319
IntAct Q99816
Open Targets ENSG00000074319
PharmGKB PA38068
Reactome R-HSA-162588 (Budding and maturation of HIV virion.)
R-HSA-174490 (Membrane binding and targetting of GAG proteins.)
R-HSA-917729 (Endosomal Sorting Complex Required For Transport (ESCRT).)
UniProt Q99816 Q9BUM5

Target Cross References - Domain

InterPro IPR008883 (UEV_N.)
IPR016135 (UBQ-conjugating_enzyme/RWD.)
IPR017916 (SB_dom.)
Pfam PF05743 (UEV)
PF09454 (Vps23_core)

Target Cross References - Structure

PDBe 1S1Q 2F0R 3IV1 3OBQ 3OBS 3OBU 3OBX 3P9G 3P9H 4EJE 4YC1 4ZNY
CREDO 1S1Q 2F0R 3IV1 3OBQ 3OBS 3OBU 3OBX 3P9G 3P9H 4EJE 4YC1 4ZNY
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