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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL6156
Target Type SINGLE PROTEIN
Preferred Name Tripeptidyl-peptidase 2
Synonyms TPP-2 | TPP-II | TPP2 | Tripeptidyl aminopeptidase | Tripeptidyl-peptidase 2 | Tripeptidyl-peptidase II
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > protease > serine protease > serine protease sb clan > serine protease s8a subfamily

Target Components

Component Description Relationship Accession
Tripeptidyl-peptidase 2 SINGLE PROTEIN P29144

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000134900
Ensembl ENSG00000134900
GO Cellular Component GO:0005634 (nucleus)
GO:0005737 (cytoplasm)
GO:0005829 (cytosol)
GO Molecular Function GO:0004175 (endopeptidase activity)
GO:0004177 (aminopeptidase activity)
GO:0004252 (serine-type endopeptidase activity)
GO:0005515 (protein binding)
GO:0008233 (peptidase activity)
GO:0008236 (serine-type peptidase activity)
GO:0008240 (tripeptidyl-peptidase activity)
GO:0016787 (hydrolase activity)
GO:0042277 (peptide binding)
GO Biological Process GO:0000209 (protein polyubiquitination)
GO:0006508 (proteolysis)
Wikipedia Tripeptidyl_peptidase_II

Target Cross References - Protein

canSAR P29144
Human Protein Atlas ENSG00000134900
IntAct P29144
Guide to Pharmacology 2423
Open Targets ENSG00000134900
PharmGKB PA36695
Reactome R-HSA-983168 (Antigen processing: Ubiquitination & Proteasome degradation.)
UniProt P29144 Q5VZU8

Target Cross References - Domain

InterPro IPR000209 (Peptidase_S8/S53_dom.)
IPR015500 (Peptidase_S8_subtilisin-rel.)
IPR022229 (Peptidase_S8A_TPPII.)
IPR022398 (Peptidase_S8_His-AS.)
IPR023828 (Peptidase_S8_Ser-AS.)
IPR034051 (TPP_II_domain.)
Pfam PF00082 (Peptidase_S8)
PF12580 (TPPII)
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