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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL6155
Target Type SINGLE PROTEIN
Preferred Name Thiamin pyrophosphokinase 1
Synonyms PP20 | Placental protein 20 | TPK1 | Thiamin pyrophosphokinase 1 | Thiamine pyrophosphokinase 1 | hTPK1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Thiamin pyrophosphokinase 1 SINGLE PROTEIN Q9H3S4

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000196511
Ensembl ENSG00000196511
GO Cellular Component GO:0005829 (cytosol)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0004788 (thiamine diphosphokinase activity)
GO:0005524 (ATP binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO:0030975 (thiamine binding)
GO Biological Process GO:0006772 (thiamine metabolic process)
GO:0009229 (thiamine diphosphate biosynthetic process)
GO:0016310 (phosphorylation)
GO:0042723 (thiamine-containing compound metabolic process)
Wikipedia TPK1

Target Cross References - Protein

canSAR Q9H3S4
CGD Thiamine metabolism dysfunction syndrome 5
Human Protein Atlas ENSG00000196511
IntAct Q9H3S4
Open Targets ENSG00000196511
PharmGKB PA38235
Pharos Q9H3S4 (Tbio)
Reactome R-HSA-196819 (Vitamin B1 (thiamin) metabolism.)
UniProt A8K0T7 D3DWG0 I6L9B8 Q6NUR5 Q9H3S4 Q9H602

Target Cross References - Domain

InterPro IPR006282 (Thi_PPkinase.)
IPR007371 (TPK_catalytic.)
IPR007373 (Thiamin_PyroPKinase_B1-bd.)
IPR016966 (Thiamin_pyrophosphokinase_euk.)
Pfam PF04263 (TPK_catalytic)
PF04265 (TPK_B1_binding)

Target Cross References - Structure

PDBe 3S4Y
CREDO 3S4Y
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