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Target Report Card

Target Name and Classification

Target ID CHEMBL6152
Target Type SINGLE PROTEIN
Preferred Name Alpha-synuclein
Synonyms Alpha-synuclein | NACP | NACP | Non-A beta component of AD amyloid | Non-A4 component of amyloid precursor | PARK1 | SNCA
Organism Homo sapiens
Species Group No
Protein Target Classification
  • unclassified protein

Target Components

Component Description Relationship Accession
Alpha-synuclein SINGLE PROTEIN P37840

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL3833330 BIIB054 Alpha-synuclein inhibitor 2

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000145335
Ensembl ENSG00000145335
GO Cellular Component GO:0005576 (extracellular region)
GO:0005615 (extracellular space)
GO:0005634 (nucleus)
GO:0005640 (nuclear outer membrane)
GO:0005737 (cytoplasm)
GO:0005739 (mitochondrion)
GO:0005741 (mitochondrial outer membrane)
GO:0005743 (mitochondrial inner membrane)
GO:0005747 (mitochondrial respiratory chain complex I)
GO:0005758 (mitochondrial intermembrane space)
GO:0005759 (mitochondrial matrix)
GO:0005764 (lysosome)
GO:0005791 (rough endoplasmic reticulum)
GO:0005794 (Golgi apparatus)
GO:0005829 (cytosol)
GO:0005840 (ribosome)
GO:0005856 (cytoskeleton)
GO:0005886 (plasma membrane)
GO:0005938 (cell cortex)
GO:0008021 (synaptic vesicle)
GO:0015629 (actin cytoskeleton)
GO:0016020 (membrane)
GO:0016234 (inclusion body)
GO:0030054 (cell junction)
GO:0030424 (axon)
GO:0030426 (growth cone)
GO:0030659 (cytoplasmic vesicle membrane)
GO:0031092 (platelet alpha granule membrane)
GO:0043025 (neuronal cell body)
GO:0043195 (terminal bouton)
GO:0043231 (intracellular membrane-bounded organelle)
GO:0043679 (axon terminus)
GO:0045202 (synapse)
GO:0048471 (perinuclear region of cytoplasm)
GO:0098793 (presynapse)
GO:0098794 (postsynapse)
GO:0099512 (supramolecular fiber)
GO Molecular Function GO:0000287 (magnesium ion binding)
GO:0005504 (fatty acid binding)
GO:0005507 (copper ion binding)
GO:0005509 (calcium ion binding)
GO:0005515 (protein binding)
GO:0005543 (phospholipid binding)
GO:0008017 (microtubule binding)
GO:0008198 (ferrous iron binding)
GO:0008270 (zinc ion binding)
GO:0016491 (oxidoreductase activity)
GO:0019894 (kinesin binding)
GO:0019899 (enzyme binding)
GO:0019904 (protein domain specific binding)
GO:0030544 (Hsp70 protein binding)
GO:0042393 (histone binding)
GO:0042802 (identical protein binding)
GO:0043014 (alpha-tubulin binding)
GO:0043027 (cysteine-type endopeptidase inhibitor activity involved in apoptotic process)
GO:0043274 (phospholipase binding)
GO:0044212 (transcription regulatory region DNA binding)
GO:0046872 (metal ion binding)
GO:0047485 (protein N-terminus binding)
GO:0048156 (tau protein binding)
GO:0048487 (beta-tubulin binding)
GO:0051219 (phosphoprotein binding)
GO:0060961 (phospholipase D inhibitor activity)
GO:0070840 (dynein complex binding)
GO:1903136 (cuprous ion binding)
GO Biological Process GO:0000122 (negative regulation of transcription from RNA polymerase II promoter)
GO:0001774 (microglial cell activation)
GO:0001921 (positive regulation of receptor recycling)
GO:0001933 (negative regulation of protein phosphorylation)
GO:0001956 (positive regulation of neurotransmitter secretion)
GO:0001963 (synaptic transmission, dopaminergic)
GO:0006631 (fatty acid metabolic process)
GO:0006638 (neutral lipid metabolic process)
GO:0006644 (phospholipid metabolic process)
GO:0006915 (apoptotic process)
GO:0006919 (activation of cysteine-type endopeptidase activity involved in apoptotic process)
GO:0007006 (mitochondrial membrane organization)
GO:0007268 (chemical synaptic transmission)
GO:0007568 (aging)
GO:0008344 (adult locomotory behavior)
GO:0010040 (response to iron(II) ion)
GO:0010517 (regulation of phospholipase activity)
GO:0010642 (negative regulation of platelet-derived growth factor receptor signaling pathway)
GO:0014048 (regulation of glutamate secretion)
GO:0014059 (regulation of dopamine secretion)
GO:0031115 (negative regulation of microtubule polymerization)
GO:0031623 (receptor internalization)
GO:0031648 (protein destabilization)
GO:0032026 (response to magnesium ion)
GO:0032410 (negative regulation of transporter activity)
GO:0032496 (response to lipopolysaccharide)
GO:0032769 (negative regulation of monooxygenase activity)
GO:0033138 (positive regulation of peptidyl-serine phosphorylation)
GO:0034341 (response to interferon-gamma)
GO:0034599 (cellular response to oxidative stress)
GO:0035067 (negative regulation of histone acetylation)
GO:0040012 (regulation of locomotion)
GO:0042220 (response to cocaine)
GO:0042416 (dopamine biosynthetic process)
GO:0042417 (dopamine metabolic process)
GO:0042493 (response to drug)
GO:0042775 (mitochondrial ATP synthesis coupled electron transport)
GO:0043030 (regulation of macrophage activation)
GO:0043065 (positive regulation of apoptotic process)
GO:0043066 (negative regulation of apoptotic process)
GO:0043154 (negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)
GO:0043524 (negative regulation of neuron apoptotic process)
GO:0044267 (cellular protein metabolic process)
GO:0044344 (cellular response to fibroblast growth factor stimulus)
GO:0045807 (positive regulation of endocytosis)
GO:0045920 (negative regulation of exocytosis)
GO:0045963 (negative regulation of dopamine metabolic process)
GO:0046928 (regulation of neurotransmitter secretion)
GO:0048148 (behavioral response to cocaine)
GO:0048168 (regulation of neuronal synaptic plasticity)
GO:0048169 (regulation of long-term neuronal synaptic plasticity)
GO:0048488 (synaptic vesicle endocytosis)
GO:0048489 (synaptic vesicle transport)
GO:0050729 (positive regulation of inflammatory response)
GO:0050806 (positive regulation of synaptic transmission)
GO:0050808 (synapse organization)
GO:0050812 (regulation of acyl-CoA biosynthetic process)
GO:0051281 (positive regulation of release of sequestered calcium ion into cytosol)
GO:0051583 (dopamine uptake involved in synaptic transmission)
GO:0051585 (negative regulation of dopamine uptake involved in synaptic transmission)
GO:0051612 (negative regulation of serotonin uptake)
GO:0051622 (negative regulation of norepinephrine uptake)
GO:0055074 (calcium ion homeostasis)
GO:0055114 (oxidation-reduction process)
GO:0060079 (excitatory postsynaptic potential)
GO:0060291 (long-term synaptic potentiation)
GO:0060732 (positive regulation of inositol phosphate biosynthetic process)
GO:0061024 (membrane organization)
GO:0070495 (negative regulation of thrombin receptor signaling pathway)
GO:0070555 (response to interleukin-1)
GO:0071280 (cellular response to copper ion)
GO:0071872 (cellular response to epinephrine stimulus)
GO:0071902 (positive regulation of protein serine/threonine kinase activity)
GO:0097435 (fibril organization)
GO:1901214 (regulation of neuron death)
GO:1901215 (negative regulation of neuron death)
GO:1901216 (positive regulation of neuron death)
GO:1902957 (negative regulation of mitochondrial electron transport, NADH to ubiquinone)
GO:1903284 (positive regulation of glutathione peroxidase activity)
GO:1903285 (positive regulation of hydrogen peroxide catabolic process)
GO:1903421 (regulation of synaptic vesicle recycling)
GO:1903426 (regulation of reactive oxygen species biosynthetic process)
GO:1904307 (response to desipramine)
GO:1904715 (negative regulation of chaperone-mediated autophagy)
GO:1905606 (regulation of presynapse assembly)
GO:2000377 (regulation of reactive oxygen species metabolic process)
Wikipedia Alpha-synuclein

Target Cross References - Protein

canSAR P37840
CGD Parkinson disease; Dementia with Lewy bodies
Human Protein Atlas ENSG00000145335
IntAct P37840
Open Targets ENSG00000145335
PharmGKB PA35986
Reactome R-HSA-977225 (Amyloid fiber formation.)
UniProt A8K2A4 P37840 Q13701 Q4JHI3 Q6IAU6

Target Cross References - Domain

InterPro IPR001058 (Synuclein.)
IPR002460 (Synuclein_alpha.)
Pfam PF01387 (Synuclein)

Target Cross References - Structure

PDBe 2X6M 3Q25 3Q26 3Q27 3Q28 3Q29 4R0U 4R0W 4RIK 5CRW
CREDO 2X6M 3Q25 3Q26 3Q27 3Q28 3Q29 4R0U 4R0W 4RIK 5CRW
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