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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL6144
Target Type SINGLE PROTEIN
Preferred Name G protein-coupled receptor kinase 6
Synonyms G protein-coupled receptor kinase 6 | G protein-coupled receptor kinase GRK6 | GPRK6 | GRK6
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > agc protein kinase group > agc protein kinase grk family > agc protein kinase grk subfamily

Target Components

Component Description Relationship Accession
G protein-coupled receptor kinase 6 SINGLE PROTEIN P43250

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000198055
Ensembl ENSG00000198055
GO Cellular Component GO:0005829 (cytosol)
GO:0005886 (plasma membrane)
GO:0016020 (membrane)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0004672 (protein kinase activity)
GO:0004674 (protein serine/threonine kinase activity)
GO:0004703 (G-protein coupled receptor kinase activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO:0047696 (beta-adrenergic receptor kinase activity)
GO Biological Process GO:0002029 (desensitization of G-protein coupled receptor protein signaling pathway)
GO:0006468 (protein phosphorylation)
GO:0007165 (signal transduction)
GO:0008277 (regulation of G-protein coupled receptor protein signaling pathway)
GO:0010360 (negative regulation of anion channel activity)
GO:0016055 (Wnt signaling pathway)
GO:0016310 (phosphorylation)
Wikipedia GRK6

Target Cross References - Protein

canSAR P43250
Human Protein Atlas ENSG00000198055
IntAct P43250
Guide to Pharmacology 1470
Open Targets ENSG00000198055
PharmGKB PA28942
Pharos P43250 (Tbio)
Reactome R-HSA-418555 (G alpha (s) signalling events.)
UniProt O60541 P43250 Q13652

Target Cross References - Domain

InterPro IPR000239 (GPCR_kinase.)
IPR000719 (Prot_kinase_dom.)
IPR000961 (AGC-kinase_C.)
IPR008271 (Ser/Thr_kinase_AS.)
IPR011009 (Kinase-like_dom.)
IPR016137 (RGS.)
IPR017441 (Protein_kinase_ATP_BS.)
Pfam PF00069 (Pkinase)
PF00615 (RGS)

Target Cross References - Structure

PDBe 2ACX 3NYN 3NYO
CREDO 2ACX 3NYN 3NYO
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