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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL6122
Target Type SINGLE PROTEIN
Preferred Name Group XIIA secretory phospholipase A2
Synonyms GXII sPLA2 | Group XIIA secretory phospholipase A2 | PLA2G12 | PLA2G12A | Phosphatidylcholine 2-acylhydrolase 12A | UNQ2519/PRO6012 | sPLA2-XII
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Group XIIA secretory phospholipase A2 SINGLE PROTEIN Q9BZM1

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000123739
Ensembl ENSG00000123739
GO Cellular Component GO:0005576 (extracellular region)
GO:0005622 (intracellular)
GO:0005737 (cytoplasm)
GO:0005783 (endoplasmic reticulum)
GO:0005794 (Golgi apparatus)
GO Molecular Function GO:0004623 (phospholipase A2 activity)
GO:0005509 (calcium ion binding)
GO:0016787 (hydrolase activity)
GO:0046872 (metal ion binding)
GO:0047498 (calcium-dependent phospholipase A2 activity)
GO Biological Process GO:0006629 (lipid metabolic process)
GO:0006654 (phosphatidic acid biosynthetic process)
GO:0008150 (biological_process)
GO:0016042 (lipid catabolic process)
GO:0036148 (phosphatidylglycerol acyl-chain remodeling)
GO:0036149 (phosphatidylinositol acyl-chain remodeling)
GO:0036150 (phosphatidylserine acyl-chain remodeling)
GO:0036151 (phosphatidylcholine acyl-chain remodeling)
GO:0036152 (phosphatidylethanolamine acyl-chain remodeling)
Wikipedia PLA2G12A

Target Cross References - Protein

canSAR Q9BZM1
Human Protein Atlas ENSG00000123739
IntAct Q9BZM1
Open Targets ENSG00000123739
PharmGKB PA38347
Reactome R-HSA-1482788 (Acyl chain remodelling of PC.)
R-HSA-1482801 (Acyl chain remodelling of PS.)
R-HSA-1482839 (Acyl chain remodelling of PE.)
R-HSA-1482922 (Acyl chain remodelling of PI.)
R-HSA-1482925 (Acyl chain remodelling of PG.)
R-HSA-1483166 (Synthesis of PA.)
UniProt Q9BZ89 Q9BZM1

Target Cross References - Domain

InterPro IPR010711 (PLA2G12.)
IPR016090 (PLipase_A2_dom.)
IPR033113 (PLipase_A2_His_AS.)
Pfam PF06951 (PLA2G12)
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