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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL6120
Preferred Name Solute carrier family 22 member 12
Synonyms OATL4 | Organic anion transporter 4-like protein | RST | Renal-specific transporter | SLC22A12 | Solute carrier family 22 member 12 | URAT1 | Urate anion exchanger 1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • transporter > electrochemical transporter > slc superfamily of solute carriers > slc22 family of organic cation and anion transporters

Target Components

Component Description Relationship Accession
Solute carrier family 22 member 12 SINGLE PROTEIN Q96S37

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL832 SULFINPYRAZONE Solute carrier family 22 member 12 inhibitor 4 PubMed PubMed
CHEMBL388590 BENZBROMARONE Solute carrier family 22 member 12 inhibitor 4 PubMed PubMed PubMed PubMed PubMed PubMed
CHEMBL2105720 LESINURAD Solute carrier family 22 member 12 inhibitor 4 FDA
CHEMBL41194 PRATOSARTAN Solute carrier family 22 member 12 inhibitor 2 PubMed
CHEMBL2103824 ARHALOFENATE Solute carrier family 22 member 12 inhibitor 2 Other PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000197891
Ensembl ENSG00000197891
GO Cellular Component GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0016324 (apical plasma membrane)
GO:0031526 (brush border membrane)
GO:0070062 (extracellular exosome)
GO Molecular Function GO:0005452 (inorganic anion exchanger activity)
GO:0015143 (urate transmembrane transporter activity)
GO:0015347 (sodium-independent organic anion transmembrane transporter activity)
GO:0022857 (transmembrane transporter activity)
GO:0030165 (PDZ domain binding)
GO Biological Process GO:0006811 (ion transport)
GO:0015698 (inorganic anion transport)
GO:0015747 (urate transport)
GO:0019725 (cellular homeostasis)
GO:0042493 (response to drug)
GO:0043252 (sodium-independent organic anion transport)
GO:0046415 (urate metabolic process)
GO:0055085 (transmembrane transport)
Wikipedia SLC22A12

Target Cross References - Protein

canSAR Q96S37
CGD Hypouricemia, renal 1
Human Protein Atlas ENSG00000197891
IntAct Q96S37
Guide to Pharmacology 1031
Open Targets ENSG00000197891
PharmGKB PA38478
Reactome R-HSA-561048 (Organic anion transport.)
R-HSA-5619071 (Defective SLC22A12 causes renal hypouricemia 1 (RHUC1).)
UniProt B7WPG1 G3XAN7 Q19PF7 Q19PF8 Q19PF9 Q19PG0 Q6UXW3 Q96DT2 Q96S37

Target Cross References - Domain

InterPro IPR005828 (MFS_sugar_transport-like.)
IPR020846 (MFS_dom.)
IPR036259 (MFS_trans_sf.)
Pfam PF00083 (Sugar_tr)