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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL6118
Target Type SINGLE PROTEIN
Preferred Name Quinone oxidoreductase
Synonyms CRYZ | NADPH:quinone reductase | Quinone oxidoreductase | Zeta-crystallin
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Quinone oxidoreductase SINGLE PROTEIN Q08257

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000116791
Ensembl ENSG00000116791
GO Cellular Component GO:0005737 (cytoplasm)
GO:0005829 (cytosol)
GO:0070062 (extracellular exosome)
GO Molecular Function GO:0003723 (RNA binding)
GO:0003730 (mRNA 3'-UTR binding)
GO:0003960 (NADPH:quinone reductase activity)
GO:0008270 (zinc ion binding)
GO:0016491 (oxidoreductase activity)
GO:0070402 (NADPH binding)
GO:0070404 (NADH binding)
GO Biological Process GO:0007601 (visual perception)
GO:0042178 (xenobiotic catabolic process)
GO:0051289 (protein homotetramerization)
GO:0055114 (oxidation-reduction process)
Wikipedia CRYZ

Target Cross References - Protein

canSAR Q08257
Human Protein Atlas ENSG00000116791
IntAct Q08257
Open Targets ENSG00000116791
PharmGKB PA26925
UniProt A6NN60 D3DQ76 Q08257 Q53FT0 Q59EU7 Q5HYE7 Q6NSK9

Target Cross References - Domain

InterPro IPR002364 (Quin_OxRdtase/zeta-crystal_CS.)
IPR011032 (GroES-like.)
IPR013149 (ADH_C.)
IPR013154 (ADH_N.)
IPR016040 (NAD(P)-bd_dom.)
IPR020843 (PKS_ER.)
Pfam PF00107 (ADH_zinc_N)
PF08240 (ADH_N)

Target Cross References - Structure

PDBe 1YB5
CREDO 1YB5
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